Oropharyngeal Cancer Ultrasound Diagnostic Trial, 170 Patients
Summary
A randomized controlled trial (NCT07548268) examining whether transoral and cervical ultrasound of the palatine and lingual tonsils improves diagnostic accuracy in patients with suspected oropharyngeal cancer. The study enrolls 170 patients at four Danish Head and Neck Hospital departments, comparing standard diagnostics alone against standard diagnostics supplemented by ultrasound. Endpoints include diagnostic accuracy, number of correct biopsies, imaging modalities ordered, and time to final diagnosis.
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What changed
This prospective randomized controlled trial registered on ClinicalTrials.gov (NCT07548268) will enroll 170 patients across four Danish Head and Neck Hospital departments. Participants are randomized to receive standard oropharyngeal cancer diagnostics or standard diagnostics plus transoral and cervical ultrasound of the lingual and palatine tonsils. The study measures diagnostic accuracy, correct biopsy yield, number of imaging modalities ordered, and time to final diagnosis.\n\nClinical investigators and research institutions conducting head and neck cancer diagnostics studies may find this trial relevant for study design considerations. Findings, if positive, could inform future diagnostic workup protocols for oropharyngeal carcinoma.
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Apr 24, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Transoral and Cervical Ultrasound of Patients With Suspected Oropharyngeal Cancer
N/A NCT07548268 Kind: NA Apr 23, 2026
Abstract
Introduction The current diagnostic approach for patients with suspected oropharyngeal cancer involves a combination of clinical examination, tissue sampling, and relevant cross-sectional imaging. Previous studies have shown that transoral and cervical ultrasound (US) of the palatine and lingual tonsils has a better diagnostic accuracy than clinical investigation and magnetic resonance imaging (MRI) in patients with suspected oropharyngeal cancer, but it has not been established whether adding this scan to the diagnostic workup has a clinical impact.
Methods A randomized controlled study, including 170 patients at four different Head and Neck Hospital departments in Denmark. One group receives standard diagnostics (control group), and the other group receives standard diagnostics supplemented by transoral and cervical ultrasound of the lingual and palatine tonsils. The diagnostic accuracy, number of correct biopsies, number of imaging modalities ordered, and time to final diagnosis are noted.
Conclusion This randomized controlled study examines whether the implementation of transoral and cervical ultrasound of the palatine and lingual tonsils in patients with suspected oropharyngeal cancer will improve the diagnostic accuracy and have a clinical impact. This concerns more accurate initial diagnoses, more correct biopsies, fewer unnecessary scans, and fewer visits to the outpatient clinic.
Conditions: Oropharyngeal Carcinoma, Ultrasound
Interventions: Ultrasound of the oropharynx
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