Condensed Pyrazole Derivatives as Inhibitors of SARM1
Summary
The USPTO granted patent US12606558B2 to Disarm Therapeutics, Inc. covering condensed pyrazole derivatives useful as SARM1 inhibitors for treating and preventing axonal degeneration. The patent, granted April 21, 2026, contains 10 claims and names six inventors including Jonathan Bentley Jr. and Robert Owen Hughes.
About this source
GovPing monitors USPTO Patent Grants - Therapeutics (A61P) for new healthcare & life sciences regulatory changes. Every update since tracking began is archived, classified, and available as free RSS or email alerts — 190 changes logged to date.
What changed
The USPTO granted patent US12606558B2 to Disarm Therapeutics, Inc. covering compounds of formula (I) useful for inhibiting SARM1 and treating or preventing axonal degeneration. The patent contains 10 claims and is classified under CPC codes A61P 25/28 (nervous system disorders) and A61P 25/02 (neuronal disorders).
For biotechnology and pharmaceutical companies developing SARM1-targeted therapeutics for neurological conditions, this patent establishes intellectual property protection for pyrazole-based SARM1 inhibitors. Parties pursuing similar compounds or axonal degeneration treatments should review Freedom to Operate positions and consider licensing discussions with the patent holder.
Archived snapshot
Apr 21, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Condensed pyrazole derivatives as inhibitors of SARM1
Grant US12606558B2 Kind: B2 Apr 21, 2026
Assignee
Disarm Therapeutics, Inc.
Inventors
Jonathan Bentley, Jr., Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
Abstract
The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
CPC Classifications
A61P 25/28 A61P 25/02 C07D 471/04 C07D 498/04
Filing Date
2021-04-07
Application No.
17995049
Claims
10
Mentioned entities
Parties
Related changes
Get daily alerts for USPTO Patent Grants - Therapeutics (A61P)
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
Source
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from USPTO.
The summary, classification, recommended actions, deadlines, and penalty information are AI-generated from the original text and may contain errors. Always verify against the source document.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when USPTO Patent Grants - Therapeutics (A61P) publishes new changes.
Subscribed!
Optional. Filters your digest to exactly the updates that matter to you.