Porous Silicon Nanoparticle Drug Delivery System with Reactive Oxygen Species Self-Activation, Kyung Hee University

The USPTO issued Patent US12605462B2 for a porous silicon nanoparticle composition designed for controlled drug delivery. The nanoparticles are conjugated with isothiocyanate moiety on the surface, enabling self-generation of reactive oxygen species intracellularly without requiring external initiators, which facilitates drug release through decomposition. The patent covers the composition, method of preparation, and therapeutic applications including anticancer uses (A61P 35/00). The assignee is Kyung Hee University's industry cooperation group with inventors Do Kyoung Kim and Rae Hyung Kang.

For pharmaceutical and biotechnology companies developing drug delivery systems, this patent establishes IP protection around isothiocyanate-conjugated porous silicon nanoparticle technology. Companies working on intracellular ROS-triggered drug release mechanisms should conduct freedom-to-operate analyses before similar product development.