Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes
ClinicalTrials.gov Studies
Summary
This clinical trial registration (NCT07546409) describes a randomized study assessing whether older adults with prediabetes show differences in brain glucose uptake and cognitive processing speed compared to age-matched controls with normal glucose levels. The trial will test a single dose of an exogenous ketone monoester supplement (DeltaG) against placebo in approximately 100 participants, measuring outcomes via 18F-FDG-PET/MRI brain imaging and cognitive testing. Estimated study completion date is April 22, 2026.
“The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with normal blood sugar levels.”
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What changed
This ClinicalTrials.gov registration entry documents a new interventional study (NCT07546409) examining ketone supplement effects on brain function. The trial will enroll approximately 100 older adults with and without prediabetes, administering a single dose of ketone monoester (DeltaG, Oxford, England) or placebo during brain imaging sessions. Participants will undergo metabolic testing, 18F-FDG-PET/MRI imaging during cognitive tasks, and standardized cognitive testing to measure processing speed and brain glucose uptake.\n\nFor compliance purposes, this registration represents routine scientific disclosure rather than a regulatory action. Healthcare institutions and research sponsors conducting similar cognitive or metabolic intervention trials should note the imaging protocol (FDG-PET/MRI) and the specific outcome measures (cognitive processing speed, brain glucose uptake) as benchmarks for peer studies.
Archived snapshot
Apr 22, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?
N/A NCT07546409 Kind: NA Apr 22, 2026
Abstract
Brief Summary
The goal of this clinical trial is to learn whether older adults with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and thinking speed compared to older adults with normal blood sugar levels. The study will also test whether a single dose of an exogenous ketone supplement can improve brain energy use and cognitive processing speed.
The main questions it aims to answer are:
Do older adults with prediabetes have lower brain glucose uptake and slower cognitive processing speed compared to those with normal glucose levels?
Does a single dose of an exogenous ketone monoester supplement improve cognitive processing speed and brain glucose uptake?
Researchers will compare older adults with prediabetes to older adults with normal glucose levels to determine whether differences exist in brain glucose metabolism and cognitive performance. In a subset of participants, researchers will also compare brain and cognitive outcomes before and after consuming a ketone monoester supplement (DeltaG, Oxford, England).
Participants will:
Complete metabolic testing to determine glucose status
Undergo brain imaging using fluorodeoxyglucose positron emission tomography combined with magnetic resonance imaging (18FDG-PET/MRI) while performing a cognitive processing speed task
Consume a single dose of a commercially available ketone monoester supplement during one study visit
Complete cognitive testing during imaging to measure pro...
Conditions: Prediabetes, Healthy (Controls)
Interventions: Ketone Monoester (KE), Placebo
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