Healthcare & Life Sciences

Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department

NIH has registered a new clinical trial (NCT07536594) on ClinicalTrials.gov comparing intravenous lidocaine to morphine for acute renal colic pain management in emergency departments. The trial aims to address the opioid epidemic by investigating whether lidocaine can serve as an effective non-opioid alternative for pain management. Researchers plan to recruit a diverse population to build on preliminary evidence from a 2012 Iranian study.

Effect of Complete Suction-Induced Collapse of Renal Collecting System at End of RIRS on Early Postoperative Outcomes

NIH ClinicalTrials.gov has registered NCT07535281, a randomized controlled trial evaluating whether actively suctioning the renal collecting system to induce collapse at the end of retrograde intrarenal surgery (RIRS) reduces postoperative pain and infection in kidney stone patients. Participants will be randomly assigned to experimental group (suction-induced collapse) or control group (standard drainage). The study aims to determine if this surgical modification improves early recovery outcomes and patient satisfaction.

Michigan Awards Healthy Kids Dental Contract to Delta Dental of Michigan

Michigan DHHS awarded the Healthy Kids Dental (HKD) contract to Delta Dental of Michigan. The program covers approximately 955,000 children under age 21 enrolled in Medicaid. The five-year contract begins October 1, 2026, with three one-year extension options.

Measles Case in Saluda County Adult, 34 Exposed

South Carolina DPH confirmed a measles case in a Saluda County adult linked to international travel. Lab confirmation was received April 16. Thirty-four individuals have been identified as potentially exposed and are being notified for quarantine. No public exposures occurred. This brings the state total to 1,001 measles cases since July 2025, while the unrelated Upstate outbreak (997 cases) is scheduled to be declared over April 26.

Seven-Year Radiographic Retention Study, Four Implant Overdenture

NIH's ClinicalTrials.gov registered a retrospective observational study (NCT07536776) examining marginal bone loss and retention outcomes in 27 completely edentulous patients receiving four-implant LOCATOR-retained mandibular overdentures over a seven-year follow-up period. The study assesses bone loss and retention at baseline, one year, and seven years post-insertion. Enrollment opens April 17, 2026.

Co-supplementation With Bifidobacterium Longum W11 and Colopectin for Maintenance Therapy in Children With Functional Constipation

The NIH ClinicalTrials.gov registry has recorded a new randomized, double-blind, placebo-controlled trial (NCT07536698) evaluating co-supplementation with Bifidobacterium longum W11 and Colopectin for maintenance therapy in children aged 2 to 6 years with functional constipation receiving macrogol. The study will enroll participants for 4 weeks of active treatment followed by 4 weeks of follow-up after treatment discontinuation, assessing constipation persistence, stool consistency, evacuation distress, soiling episodes, and treatment compliance.

Auricular Point Stimulation Plus Dexamethasone for Chemotherapy Nausea

NIH registered a Phase 2 clinical trial (NCT07537660) on ClinicalTrials.gov evaluating auricular point stimulation combined with dexamethasone for preventing chemotherapy-induced nausea and vomiting in pancreatic cancer patients receiving gemcitabine plus paclitaxel protein-bound treatment. The trial aims to enroll participants who will receive auricular acupressure with bean seeds plus IV dexamethasone as an antiemetic, with a primary completion date of April 17, 2026.

Observational Study Recording Stress Biomarkers in Autism Spectrum Disorders

The National Institutes of Health registered an observational clinical trial (NCT07535801) studying how physiological stress signals differ between children and young people with autism spectrum disorder (ASD) and non-ASD participants. The study will monitor two biological stress systems — the autonomic nervous system and the hypothalamic-pituitary-adrenal axis — in real-life environments including schools, homes, and care institutions. Participants with ASD who also have intellectual deficiency will be compared against a control group of typically developing peers.

GEA Simultaneous to VSG Reduces Post-operative GERD

NIH registered a clinical trial (NCT07537244) to evaluate whether adding gastroenteroanastomosis (GEA) to vertical sleeve gastrectomy (VSG) reduces post-operative gastroesophageal reflux disease (GERD) in obese patients. The randomized study will compare Group A (VSG with GEA) versus Group B (VSG without GEA) using symptom questionnaires during follow-up visits. All exams are part of standard surgical or GERD follow-up routines, with an estimated start date of April 17, 2026.

Extended Time Window IV Thrombolysis Registry for Acute Ischemic Stroke

The NIH registered a new observational study (NCT07536074) titled EXTEND-IVT Registry on ClinicalTrials.gov. The study will evaluate the effectiveness and safety of intravenous thrombolysis administered beyond 4.5 hours after last known well in patients with acute ischemic stroke. The prospective, multicenter, observational cohort study will be conducted in routine clinical practice settings across China.

NCT07537569: Preoperative Oncogeriatric Assessment in Hepatectomy Patients

NIH registered clinical trial NCT07537569, a prospective study examining comprehensive geriatric assessment (CGA) in older adults scheduled for hepatectomy due to hepatic malignancies. The study aims to optimize perioperative care and improve surgical safety and recovery outcomes in elderly patients. Conditions include hepatic malignancies and comprehensive geriatric assessment with CGA as the sole intervention type.

Phase 4 Randomized Trial of Indomethacin and Paracetamol for Pain Management During IVF Oocyte Retrieval

NIH registered a Phase 4 randomized controlled trial (NCT07536425) evaluating preoperative Indomethacin (100 mg per rectum) and Paracetamol/Acamol (1,000 mg intravenously) for pain management during oocyte retrieval in women undergoing IVF or ICSI. The trial will study pain outcomes in women receiving these analgesic interventions. Conditions include Pain and Oocyte Retrieval. This is an informational clinical trial registration on ClinicalTrials.gov.

Prostate Cancer Hot Flashes ADT Smartwatch Feasibility Study

NIH ClinicalTrials.gov registered a new feasibility study (NCT07535541) titled 'A Feasibility Study of Biometric Measurements Via Wearable Smart Watch Technology for Evaluation of Vasomotor Symptoms in Patients Treated With Androgen Deprivation Therapy for Prostate Cancer.' The study will evaluate whether prostate cancer patients on ADT with vasomotor symptoms (hot flashes) consistently wear a smartwatch device to track health data and log hot flashes. Participants will wear the smartwatch for 4 weeks and complete surveys about their hot flash experiences. No compliance obligations are created for organizations.

Boil Water Advisory Rescinded for City of Humboldt, Allen County, Kansas

The Kansas Department of Health and Environment (KDHE) has rescinded a boil water advisory for the City of Humboldt public water supply system in Allen County. The advisory was originally issued due to a loss of pressure, which may result in loss of chlorine residuals and bacterial contamination. Laboratory testing of drinking water samples collected from the City of Humboldt indicates no evidence of bacteriological contamination, and all conditions that placed the system at risk are resolved.

European Patent for Kava-Derived Therapeutic Compounds and Methods of Use Thereof

EPO granted patent EP3068416A1 to Kuality Herbceutics LLC and 9 named inventors for kava-derived therapeutic compounds and methods of use. The invention is classified under IPC codes A61K 31/12, A61K 31/353, A61K 31/366 (therapeutic compounds) and A61P 35/00 (cancer treatment). The patent is designated in 36 European states including Germany, France, UK, Italy, Spain, Netherlands, Belgium, Austria, and Switzerland.

Bifunctional BTK Degrading Compounds Via Ubiquitin Proteasome Pathway

The European Patent Office published patent EP3924350A1, granted to Nurix Therapeutics, Inc., covering bifunctional compounds for degrading BTK via the ubiquitin proteasome pathway. The patent application includes six IPC classifications spanning pharmaceutical compositions and therapeutic methods. Protection extends across 31 designated European states including major markets.

UPAR Targeting Peptide for Peroperative Optical Imaging of Invasive Cancer

The EPO published patent application EP3733215A1 for Fluoguide A/S, covering a UPAR targeting peptide for peroperative optical imaging of invasive cancer. The patent names Andreas Kjaer and Morten Persson as inventors and includes designations across multiple European member states including DE, FR, GB, IT, ES, NL, and others. This publication grants intellectual property protection for the novel peptide composition and its diagnostic use in cancer surgery.

D3 Receptor Agonist Compounds; Methods of Preparation; Intermediates Thereof; and Methods of Use Thereof

EPO published patent application EP3953350A1 for D3 receptor agonist compounds filed by the United States Department of Health and Human Services. The patent covers specific chemical compounds, methods of preparation, intermediates thereof, and methods of therapeutic use.

Amgen Antigen Binding Proteins Targeting Beta-Klotho and FGF Receptors

The European Patent Office granted Amgen Inc. Patent EP3760642A1 covering human antigen binding proteins that bind beta-Klotho, FGF receptors, and complexes thereof. The patent covers therapeutic applications including treatment of metabolic conditions (A61P 3/04). The patent is designated for all 31 European states including DE, FR, GB, IT, ES, NL, SE, and 21 others.

DLL3 Targeting Chimeric Antigen Receptors and Binding Agents

EPO published patent application EP3930744A1 by Allogene Therapeutics Inc. and Pfizer Inc. for DLL3 targeting chimeric antigen receptors (CARs) and binding agents. The application classified under A61K 39/00, A61P 35/00, and C07K 16/28 covers therapeutic compositions targeting DLL3 for cancer treatment. The patent designates 31 European states including Germany, France, the United Kingdom, Italy, Spain, and other EU member states.

Neurotrophin Binding Protein p75NTR for Osteoarthritis Treatment - Patent EP3169347A1

The European Patent Office published patent application EP3169347A1 on April 8, 2026, covering neurotrophin binding protein p75NTR for use in treating osteoarthritis. Applicant Levicept Limited, invented by Simon Westbrook, received European patent protection covering A61K therapeutic compositions. The patent designates all EPC contracting states including AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, and TR.

Lonza Ltd Patents Larch Tree Arabinogalactan-Polyphenol Composition

The European Patent Office published patent application EP2638914A1 filed by Lonza Ltd, covering a composition comprising arabinogalactan and polyphenols derived from larch trees. The application, filed by inventors Freitas and Rodriguez, is classified under IPC codes A61K 36/13, A61P 31/00, and A61P 31/12, indicating therapeutic anti-infective applications. The patent designates all EU member states and additional European countries.

Integrin Alpha10 Patent for Aggressive Cancer Treatment

The European Patent Office published patent application EP3956360A1 for Integrin Alpha10 compositions and methods for treating aggressive cancer forms. Applicant Targinta AB seeks protection across 37 designated European states. The patent covers anti-integrin alpha10 antibodies and therapeutic applications for cancer treatment.

Engineered High-Affinity Human T Cell Receptors - EP3071594A1

The European Patent Office published patent application EP3071594A1 for engineered high-affinity human T cell receptors, filed by the Board of Trustees of the University of Illinois. The invention relates to engineered high-affinity human T cell receptors (TCRs) with applications in cancer immunotherapy. The application is classified under C07K 14/725, A61K 38/17, and A61P 35/00, with designation extending to all EU member states plus other European countries.

tDCS Stroke Rehabilitation Observational Study, Apr 17

This NIH ClinicalTrials.gov registry entry documents observational study NCT07535788 examining implementation of transcranial Direct Current Stimulation (tDCS) in inpatient and outpatient rehabilitation settings for stroke patients with aphasia. The study evaluates whether tDCS can be effectively integrated with routine speech therapy.

Acute Medical Unit Study, Singapore, Apr 17

NIH's ClinicalTrials.gov registered observational study NCT07536035 evaluating Acute Medical Unit care models versus standard hospital care for patients with acute medical illnesses including falls, COPD, infection, asthma, pneumonia, UTI, and URTI. The 4-year study based in Singapore will measure hospital length of stay, emergency department utilization, health quality outcomes, and cost differences across care delivery models.

Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

NIH registered clinical trial NCT07535892, a single-site pilot randomized controlled trial using a 2×2×2 factorial design to evaluate a multi-component behavioral intervention for weight loss maintenance following discontinuation of GLP-1 and anti-obesity medications. The trial will enroll participants randomized to a standardized 10-week foundational weight loss maintenance program combined with candidate support components including medically tailored meals, YMCA membership, and a structured mind-based program, with six-month follow-up.

Trans-septal Quilting Suturing vs Intranasal Silicone Splinting in Septoplasty

NIH ClinicalTrials.gov registered a randomized controlled trial (NCT07537920) comparing trans-septal quilting suturing versus intranasal silicone splinting following septoplasty in patients with deviated nasal septum. The study aims to identify which post-operative technique results in fewer adverse effects. Participants will be enrolled with an estimated completion date of April 2026.

Quadro-Iliac Plane Block vs Erector Spinae Plane Block After Total Hip Arthroplasty

NIH's ClinicalTrials.gov registered a new comparative clinical study (NCT07537036) evaluating the analgesic efficacy of Quadro-Iliac Plane Block versus Erector Spinae Plane Block in patients undergoing total hip arthroplasty. The interventional study will assign participants to receive one of two regional anesthesia techniques. This trial registration provides public transparency on ongoing medical research but does not establish regulatory compliance obligations.

Phase 4 Antihistamine Trial for HTR Prevention in 40 Children, NCT07536152

NIH registered a Phase 4 randomized, double-blinded, placebo-controlled clinical trial (NCT07536152) at a university hospital evaluating intravenous antihistamine (chlorpheniramine) versus placebo for prevention of blood transfusion-associated adverse reactions in 40 children undergoing elective congenital heart defect repair with blood-primed cardiopulmonary bypass. The study will randomly assign 20 patients per group to receive a single dose immediately after separation from bypass prior to protamine administration.

Prospective Longitudinal EVOH Renal Embolization Study in ADPKD

NIH has registered a prospective longitudinal observational study (NCT07535385) evaluating the radiological and clinical outcomes of renal embolization using ethylene-vinyl alcohol copolymer (EVOH) in dialysis patients with autosomal dominant polycystic kidney disease (ADPKD). The study aims to assess renal volume changes, complications, and prognostic factors in affected patients. Results may inform treatment strategies for ADPKD-related renal failure.

Phase 4 Cardiac Surgery Ketamine Anti-inflammatory Trial NCT07536633

NIH ClinicalTrials.gov registered a Phase 4 clinical trial (NCT07536633) investigating the anti-inflammatory effect of ketamine in cardiac surgery patients. The randomized controlled study will evaluate intraoperative ketamine administration (1 mg/kg induction plus 2.4 mg/kg/h maintenance infusion) versus control on inflammatory markers including neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and C-reactive protein. The trial targets adult cardiac surgery patients and will assess pain scores, hospital mortality, and morbidity outcomes.

Williams Syndrome iPSC Oligodendrocyte Study

NIH's ClinicalTrials.gov has registered NCT07537374, a case-control observational study examining oligodendrocyte lineage development in children with Williams syndrome using peripheral blood-derived iPSC models. The study plans to enroll 3 children with Williams syndrome and 3 healthy controls, with samples induced into neural progenitor cells and oligodendrocyte lineage cells for in vitro studies of myelin-related gene programs and developmental trajectories.

Phase 1/2a Trial of NWRD09 for Persistent HPV16 Infection in Female Participants

The NIH ClinicalTrials.gov registry has posted a new Phase 1/2a clinical trial (NCT07536282) evaluating NWRD09, an investigational drug, for the treatment of persistent HPV16 infection in female participants. The two-part study will assess safety, tolerability, immunogenicity, and efficacy while determining the maximum tolerated dose and recommended Phase 2 dose. Participants will receive either NWRD09 or placebo as part of the study design.

Sleep Quality, Cognition, and Disease Severity in Parkinson's Disease - NCT07536490

The NIH National Library of Medicine registered an observational study (NCT07536490) on ClinicalTrials.gov investigating the relationship between sleep quality, cognitive function, and disease severity in individuals with Parkinson's disease. The single-session study will assess participants using standardized tools including the Stroop Test, Clock Drawing Test, Montreal Cognitive Assessment, Unified Parkinson's Disease Rating Scale, and Modified Hoehn and Yahr Scale. The study enrolls participants diagnosed with Parkinson Disease.

Lullabies and White Noise Breastfeeding Study

NIH registered clinical trial NCT07537218 on ClinicalTrials.gov. The randomized controlled experimental study examines the effect of lullabies and white noise on breastfeeding success in newborns. The study enrolled 160 newborns divided into four groups: female voice lullaby, male voice lullaby, white noise, and control, with data collected using the LATCH Breastfeeding Assessment Scale.

ESP Block Trial for Postoperative Spinal Pain Relief

NIH registered clinical trial NCT07537647, titled 'The Effect of Bilateral Erector Spina Plane Block on Postoperative Pain in Spinal Surgery.' The trial studies whether ultrasound-guided ESP block with bupivacaine reduces postoperative pain in patients undergoing lumbar spinal stabilization surgery. The study was registered on ClinicalTrials.gov and is listed as not yet recruiting with an estimated completion date of April 17, 2026.

Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS

NIH registered an observational clinical trial (NCT07535242) investigating whether serum biomarkers GFAP, NfL, and VEGF serve as indicators of clinical progression in progressive multiple sclerosis. The study aims to better understand MS pathophysiology through biomarker analysis. This registry entry provides transparency on ongoing research but imposes no regulatory obligations on affected parties.

Risk Factors and Prediction Model for Liver-Related Outcomes in Elderly Patients With Steatotic Liver Disease

NIH registered a retrospective cohort study (NCT07537829) on steatotic liver disease in elderly patients. The single-center observational study will analyze approximately 10,000 participants aged 60 and older from the Nanjing Elderly Steatotic Liver Disease Cohort to investigate liver-related and extrahepatic adverse outcomes. Risk prediction models will be developed using machine learning algorithms; no intervention is involved.

SBRT Followed by PD-1 Inhibitor, Bevacizumab and TAS-102 as Third-Line Therapy for Recurrent/Metastatic Colorectal Cancer

NIH's ClinicalTrials.gov has registered a new Phase 2 clinical trial (NCT07535632) at Zhongshan Hospital, Fudan University in China. The trial will study stereotactic body radiotherapy (SBRT) combined with sintilimab, bevacizumab, and TAS-102 as third-line therapy for 58 patients with recurrent or metastatic colorectal cancer. The 24-month study has a primary endpoint of progression-free survival.

High-flow Nasal Cannula Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema

NIH has registered Clinical Trial NCT07536477, a randomized controlled study evaluating High-flow Nasal Cannula Oxygen Therapy (HFNC) versus Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE). The single-center trial plans to enroll 168 participants, with an estimated completion date of April 17, 2026. HFNC is the sole intervention under investigation.

PD-1 Plus Lenvatinib vs Regorafenib for Unresectable Hepatocellular Carcinoma

NIH ClinicalTrials.gov registered a new Phase 2/3 clinical trial (NCT07537985) comparing the efficacy and safety of PD-1 inhibitor combined with Lenvatinib versus PD-1 inhibitor combined with Regorafenib for unresectable hepatocellular carcinoma (UHCC) after failure of first-line treatment with bevacizumab plus sintilimab. The study aims to provide evidence-based guidance for selecting optimal second-line treatment regimens. Estimated enrollment and completion date are listed in the registry.

Ego-Tucking: Exploring Psychological Mechanisms of Fo-xi Phenomenon Among University Students

The NIH registered observational study NCT07536711 on ClinicalTrials.gov examining psychological mechanisms, stress, and mental fatigue among university students. The cross-sectional study uses a structured questionnaire to explore individual experiences, family dynamics, and macro-social environments contributing to behavioral changes in academic and professional competition contexts.

Phase 2 Trial for Intestinal Fluid Reinfusion Prevention of Low Anterior Resection Syndrome

NIH registered a Phase 2 clinical trial (NCT07537998) on ClinicalTrials.gov to evaluate antegrade intestinal fluid reinfusion for prevention of low anterior resection syndrome in patients with prophylactic ileal stoma. The single-center, prospective randomized controlled trial will compare intestinal fluid infusion to potable water infusion in approximately 60 participants. Participants will receive the assigned intervention at 1 month post-rectal resection until ileostomy reversal and maintain symptom diaries.

Monocyte Ratios, APRs, and Sepsis ICU Study

NIH's ClinicalTrials.gov registered a new observational study (NCT07537179) examining whether monocyte distribution, monocyte-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio can serve as biomarkers in sepsis patients in the ICU. The study will enroll patients admitted to the ICU for sepsis or those who develop sepsis during hospitalization, comparing these ratios with conventional acute phase response biomarkers.

Efficacy of Multi-Type Photolithography Flat Microstructure Lenses for Childhood Myopia Control

NIH ClinicalTrials.gov registered a clinical trial (NCT07535658) studying photolithography flat microstructure lenses for childhood myopia prevention and control. The randomized controlled trial will compare plano microstructure lenses with multi-point defocus design against Spectacle Lenses with Aspherical Lenslets (Essilor Stellest) in children over a 1-year period.

Observational Study of Language Reorganization in AVM Patients

NIH registered observational clinical trial NCT07537504 on ClinicalTrials.gov. The study investigates language function reorganization in patients with brain arteriovenous malformations (AVMs) involving language areas. Researchers will use multimodal MRI to examine functional remodeling, white matter pathway remodeling, and structural remodeling from multiple dimensions. The study aims to elaborate the role of the right cerebral hemisphere in reorganized language networks and interhemispheric interaction mechanisms.

At-Home taVNS for Neurorehabilitation in Parkinson's Disease

NIH registered a new clinical trial (NCT07536022) evaluating at-home transcutaneous auricular vagus nerve stimulation (taVNS) for neurorehabilitation in approximately 40 adults with Parkinson's Disease. The 8-week study will assess feasibility, tolerability, and preliminary efficacy of self-administered daily 1-hour taVNS sessions using a threshold-based individual dosing protocol. Secondary objectives include measuring changes in motor and non-motor symptoms and examining neural network connectivity via MRI.

Wildfire Smoke Lung Health Study, Canada, Asthma COPD

NIH registered a clinical trial (NCT07536178) titled 'Lungs on Fire' to study how wildfire smoke exposure contributes to long-term lung disease in susceptible populations. The controlled human exposure study will test varying concentrations of woodsmoke from Lodgepole Pine on participants with asthma, COPD, and lung cancer in Canada. The research aims to identify health impacts, vulnerable populations, and biological changes leading to chronic illness.

NAUTILUS Project Develops Mutation-Specific ASO for Syndromic Craniosynostoses

NIH ClinicalTrials.gov registered observational study NCT07535372 for the NAUTILUS project, developing ultra-personalized antisense oligonucleotide (ASO) therapeutics for syndromic craniosynostoses. The study targets rare genetic conditions including Crouzon, Saethre-Chotzen, Muenke, Pfeiffer, and Apert syndromes caused by FGFR1/2/3, TWIST1, and TCF12 variants. ASO design will be patient-tailored to silence gain-of-function alleles or restore expression in loss-of-function contexts.