Advancing Global Health Grant Program
Summary
The Bureau of Global Health Security and Diplomacy (GHSD) at the Department of State issued an Annual Program Statement (APS) for the Advancing Global Health initiative under PEPFAR (Assistance Listing 19.029). The program supports the America First Global Health Strategy through supplemental funding frameworks. Eligible applicants may submit Statements of Interest for specific Addenda addressing global health priorities. Funding ranges from $500,000 to $250 million, with applications closing February 14, 2027.
What changed
The Department of State's Bureau of Global Health Security and Diplomacy published an Annual Program Statement (APS DFOP0017890) establishing a supplemental framework to advance the America First Global Health Strategy under PEPFAR. The program provides standard application instructions for Statements of Interest to specific Addenda, including Outbreak Response and Child Protection. Total program funding is approximately $2.15 billion with 100 expected awards.
Organizations seeking funding should review the APS instructions and relevant Addenda on Grants.gov, confirm eligibility, and prepare application materials well before the February 14, 2027 closing date. Applicants should monitor for additional Addenda postings that may signal priority health challenges and implementation needs.
What to do next
- Review APS instructions and Addenda (Outbreak Response, Child Protection) to determine eligibility and alignment with funding priorities
- Prepare and submit Statement of Interest through Grants.gov before the February 14, 2027 deadline
- Monitor Grants.gov for future Addenda that may address additional health priorities
Source document (simplified)
Advancing Global Health
Agency: Bureau of Global Health Security and Diplomacy
Assistance Listings: 19.029 -- The U.S. President's Emergency Plan for AIDS Relief Programs
Last Updated: March 30, 2026 View version history on Grants.gov
Description
The Department of State invites eligible applicants to advance the America First Global Health Strategy, which aims to save lives, strengthen health systems, enhance efficiency, foster self-reliance, and ensure U.S. investments benefit American safety, strength, and prosperity. This Annual Program Statement (APS) establishes a supplemental framework through which the Department of State may identify and support projects that complement, extend, and/or fill identified gaps in the implementation of these bilateral MOUs. Through specific Addenda, the Department will signal priorities and needs. This... APS provides the standard application instructions for the submission of all Statements of Interest (SOIs) to these specific Addenda. GHSD will collaborate with Embassies and other Department of State Bureaus and Offices to post specific funding opportunities through Addenda to this APS that address health challenges and priorities of importance. Show full description
Eligibility
Eligible applicants
Miscellaneous
- Unrestricted
Additional information
Please see APS instructions for eligibility criteria.
Grantor contact information
Description
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Documents
Download all
| File name | Description | Last updated |
| --- | --- | --- |
| DFOP0017890GHSDAdvancingGlobalHealthAPSOutbreakResponseAddendum.pdf | DFOP0017890 GHSD Advancing Global Health APS Outbreak Response Addendum | Mar 30, 2026 05:47 PM UTC |
| DFOP0017890GHSDAdvancingGlobalHealthAPSAmendedasHighlighted_3-30-2026.pdf | DFOP0017890 Advancing Global Health APS | Mar 30, 2026 05:46 PM UTC |
| DFOP0017890GHSDAdvancingGlobalHealthAPSChildProtectionAddendum.pdf | DFOP0017890 GHSD Advancing Global Health APS Child Protection Addendum | Mar 30, 2026 05:47 PM UTC |
Link to additional information
Link to Opportunity in MyGrants
Closing: February 14, 2027
Application process
This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates. View on Grants.gov
Award
$2,147,483,647
Program Funding
100
Expected awards
$500,000
Award Minimum
$250,000,000
Award Maximum
Funding opportunity number:
DFOP0017890
Cost sharing or matching requirement:
No Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
-- Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
March 30, 2026
Archive date:
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