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Johns Hopkins Tolerogenic Antigen-Presenting Cell Patent US12605463B2

The USPTO granted patent US12605463B2 to Johns Hopkins University covering biodegradable particles designed to interact with immune cells and generate immunosuppressive effects. The particles include a polyester or polyester blend with soluble protein or small molecule encapsulated within, and two surface-attached protein types acting as Signal 1 and Signal 2 for immune cell binding and co-stimulation. The invention claims methods for inducing regulatory T cells and treating autoimmune diseases.

ELTA Patent - Enzymatic ADP-ribose Labeling Methods

USPTO granted patent US12601734B2 to Johns Hopkins University covering ELTA (Enzymatic Labeling of Terminal ADP-ribose) technology for labeling free, protein-conjugated, or nucleic acid-conjugated ADP-ribose molecules at their 2'-OH termini. The patent contains 28 claims and covers applications including fluorescence-based biophysical measurement of PAR-protein interaction, detection of PAR length from cells, and enrichment of ADP-ribosylated peptides for mass spectrometry identification.