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Element Biosciences PCR-Free Library Preparation Patent Granted

The USPTO granted US Patent 12,606,819B2 to Element Biosciences, Inc. covering compositions and methods for PCR-free library preparation using double-stranded splint adaptors. The patent claims double-stranded splint adaptor structures with long and short hybridized strands carrying adaptor sequences, as well as one-pot multi-enzyme reaction workflows for introducing new adaptor sequences into library molecules. The patent contains 30 claims across CPC classifications including C12N 15/1065 and C12Q 1/6855.