Wildfire Smoke Lung Health Study, Canada, Asthma COPD
ClinicalTrials.gov Studies
Summary
NIH registered a clinical trial (NCT07536178) titled 'Lungs on Fire' to study how wildfire smoke exposure contributes to long-term lung disease in susceptible populations. The controlled human exposure study will test varying concentrations of woodsmoke from Lodgepole Pine on participants with asthma, COPD, and lung cancer in Canada. The research aims to identify health impacts, vulnerable populations, and biological changes leading to chronic illness.
What changed
NIH registered a new clinical trial on ClinicalTrials.gov to investigate the long-term health impacts of repeated wildfire smoke exposure on respiratory disease. The controlled human exposure study will examine how varying concentrations of Lodgepole Pine woodsmoke affect participants with asthma, COPD, and lung cancer, with the goal of identifying vulnerable populations and biological mechanisms leading to chronic illness.
Clinical investigators and healthcare researchers conducting respiratory or environmental health studies should note this registry for context on ongoing research in this area. The study represents NIH investment in understanding climate-related health risks and may inform future public health guidance on wildfire smoke exposure.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada
N/A NCT07536178 Kind: NA Apr 17, 2026
Abstract
Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated exposure contributes to long-term lung disease. This study is a controlled human exposure to varying concentrations of WFS in a safe setting. By comparing the effects of different concentrations, this research will improve understanding of health impacts, identify who may be most vulnerable to exposures, and explore biological changes that could lead to chronic illness.
Conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer
Interventions: Woodsmoke (Lodgepole Pine) exposure, Filtered air exposure
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