Fontan Outcomes in Oligemia vs Plethora in Univentricular CHD

NIH added a new clinical trial registration for an observational study comparing outcomes between pulmonary oligemia and pulmonary plethora in patients with univentricular heart physiology undergoing the Fontan procedure. The study will enroll 52 participants and track outcomes including mortality, morbidity, pulmonary hemodynamics, functional capacity, neurocognitive status, and quality of life over approximately 1.5 years of follow-up.

Healthcare institutions conducting congenital heart disease research should note this study's focus on stratifying Fontan patients by pulmonary blood flow patterns. The study may inform future clinical decision-making regarding patient selection and risk stratification for staged palliation procedures. Patients enrolled in Fontan-related studies should discuss participation eligibility with their cardiac care teams.