Phase 2 FAPI-74 PET/CT Inflammatory Disorders Study
ClinicalTrials.gov Studies
Summary
NIH registered Phase 2 clinical trial NCT07535554 to evaluate [18F]-AlF-FAPI-74 PET/CT diagnostic performance in three inflammatory disorder cohorts: fever of unknown origin, IgG4-related disease, and axial spondyloarthritis. The study will compare the new radiopharmaceutical against standard-of-care [18F]-FDG PET/CT imaging.
What changed
NIH registered a new Phase 2 clinical trial (NCT07535554) on ClinicalTrials.gov studying [18F]-AlF-FAPI-74 PET/CT imaging in inflammatory disorders. The study will enroll patients with fever of unknown origin, IgG4-related disease, and axial spondyloarthritis, comparing the investigational radiopharmaceutical against standard [18F]-FDG PET/CT.
Healthcare providers and clinical investigators may encounter this new diagnostic imaging agent in future patient care settings. Pharmaceutical and medical device manufacturers involved in radiopharmaceutical development should note this competitive evaluation of novel PET tracers targeting fibroblast activation protein.
Archived snapshot
Apr 17, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA.
Phase 2 NCT07535554 Kind: PHASE2 Apr 17, 2026
Abstract
The aim of the study to evaluate the performance of new [18F]-AlF-FAPI-74 PET/CT in three inflammatory disorders (fever of unknown origin, IgG4-related disease and axial spondyloarthritis) and compare with the current stand-of-care [18F]-FDG PET/CT
Conditions: Fever of Unknown Origin, IgG4 Related Disease, Axial Spondylarthritis (axSpA), Inflammation of Unknown Origin
Interventions: [18F]AlF-FAPI-74 PET/CT
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