Abdominal and Lower Extremity Adipose Tissue Elasticity in Patients With Lipedema
ClinicalTrials.gov Studies
Summary
NIH has registered a new observational clinical trial (NCT07536646) investigating abdominal and lower extremity adipose tissue elasticity in patients with lipedema using shear wave elastography (SWE). The study will compare subcutaneous tissue stiffness between lipedema patients and healthy controls, and evaluate differences between abdominal and lower extremity measurements within the same patients. Lipedema is a chronic disorder predominantly affecting women and is often underrecognized or confused with obesity, venous insufficiency, and lymphedema.
What changed
NIH registered a new observational clinical trial (NCT07536646) titled 'Abdominal and Lower Extremity Adipose Tissue Elasticity in Patients With Lipedema' on ClinicalTrials.gov. The study uses shear wave elastography to compare subcutaneous tissue stiffness between lipedema patients and healthy controls, and evaluate abdominal versus lower extremity measurements within the same patients.
This trial registration provides clinical investigators and patients with information about ongoing research into lipedema, a chronic adipose tissue disorder predominantly affecting women. The study does not create compliance obligations or regulatory requirements. Interested parties may view the trial details and eligibility criteria on ClinicalTrials.gov.
Archived snapshot
Apr 17, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Abdominal and Lower Extremity Adipose Tissue Elasticity in Patients With Lipedema
Observational NCT07536646 Kind: OBSERVATIONAL Apr 17, 2026
Abstract
Lipedema is a chronic disorder characterized by abnormal bilateral fat deposition in the extremities, predominantly affecting women and typically beginning at puberty. The trunk, hands, and feet are usually spared. Despite its relatively high prevalence, lipedema is frequently underrecognized in clinical practice and is often confused with conditions such as obesity, venous insufficiency, and lymphedema. Patients commonly present with pain, tenderness, and easy bruising.
Current imaging methods have demonstrated increased subcutaneous tissue thickness and fluid infiltration in lipedema; however, no imaging modality has yet been established as a definitive diagnostic tool. Shear wave elastography (SWE) is a noninvasive ultrasound-based technique that enables quantitative assessment of tissue stiffness and may provide additional information regarding tissue structure and mechanical properties.
In this study, we aim to compare lower extremity subcutaneous tissue stiffness in patients with lipedema and healthy controls using SWE. As a secondary objective, we aim to evaluate abdominal subcutaneous tissue stiffness in patients with lipedema and compare these findings with both lower extremity measurements in the same patients and abdominal measurements in individuals without lipedema.
Conditions: Lipedema
Interventions: Shearwave elastography
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