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HEARTS Implementation for Hypertension-Diabetes Multimorbidity, Guatemala, 1,440 Adults

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Summary

NIH's ClinicalTrials.gov has registered a new clinical study (NCT07536919) evaluating the WHO-developed HEARTS implementation program for comorbid hypertension and Type 2 diabetes. The pragmatic cluster-randomized trial will enroll 1,440 adults across 36 public primary care clinics in Guatemala. Participants are randomized to HEARTS intervention or current standard care, with primary outcomes (blood pressure and hemoglobin A1c) assessed at 12 months.

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What changed

NIH's ClinicalTrials.gov registered a new clinical study (NCT07536919) investigating whether the WHO-developed HEARTS program improves care for patients with both hypertension and Type 2 diabetes in Guatemala. The pragmatic cluster-randomized controlled trial will recruit approximately 1,440 adults across 36 public primary care clinics, randomizing clinics to HEARTS implementation strategies and supply chain strengthening versus current standard care, with 12-month follow-up.

Healthcare providers and public health authorities involved in the study should ensure compliance with applicable clinical research regulations and Good Clinical Practice standards. The study does not impose regulatory compliance obligations on non-participating entities but provides a framework for integrating multimorbidity care in primary care settings.

Archived snapshot

Apr 18, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

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Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation

N/A NCT07536919 Kind: NA Apr 17, 2026

Abstract

The purpose of this study is to find out whether a program called HEARTS can improve care for people who have both high blood pressure and diabetes. HEARTS was created by the World Health Organization to help primary care clinics deliver better treatment. It includes training for health workers, simpler treatment guides, better access to medicines, teamwork among clinic staff, and tracking systems to monitor patient care. In this study, 36 public primary care clinics in Guatemala will be randomly assigned to either use the HEARTS program or continue with their current care. About 1,440 adults who have both high blood pressure and diabetes will take part. Participants will be assessed at the start of the study and again after 12 months. The main measures are blood pressure and hemoglobin A1c (a blood test that shows average blood sugar levels over the past 2 to 3 months).

Conditions: Hypertension (HTN), Type 2 Diabetes

Interventions: HEARTS implementation strategies, Supply chain strengthening

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Last updated

Classification

Agency
NIH
Published
April 17th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
NCT07536919

Who this affects

Applies to
Healthcare providers Public health authorities
Industry sector
6211 Healthcare Providers
Activity scope
Clinical research Healthcare delivery Multimorbidity care
Geographic scope
GT GT

Taxonomy

Primary area
Healthcare
Operational domain
Clinical Operations
Compliance frameworks
GxP
Topics
Public Health Pharmaceuticals

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