Comparative Efficacy of Topical Clotrimazole Versus 2% Salicylic Acid in Otomycosis
Summary
NIH has registered a randomized controlled clinical trial (NCT07535424) comparing clotrimazole ear drops versus 2% salicylic acid ear drops for treatment of otomycosis (fungal ear canal infection). The study enrolled 60 patients randomized equally between the two treatment groups, with both interventions administered three times daily for two weeks. The primary outcome measure is relief of ear blockage reflecting improvement in canal patency.
What changed
NIH registered a new clinical trial (NCT07535424) on ClinicalTrials.gov comparing clotrimazole ear drops to 2% salicylic acid ear drops for treating otomycosis. The randomized controlled study enrolled 60 patients diagnosed with otomycosis, with equal allocation to each treatment arm. Both groups received their assigned intervention three times daily for two weeks, with assessment at baseline and endpoint. The primary outcome measure is relief of ear blockage reflecting improvement in canal patency.
For healthcare providers and clinical investigators, this trial registration provides evidence of an ongoing comparative effectiveness study for a common fungal ear condition. The results may inform future treatment guidelines for selecting between these two topical antifungal options based on clinical efficacy data.
Archived snapshot
Apr 17, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Comparative Efficacy of Topical Clotrimazole Versus 2% Salicylic Acid in Otomycosis
N/A NCT07535424 Kind: NA Apr 17, 2026
Abstract
Otomycosis is a fungal infection of the outer ear canal that commonly causes itching, discomfort, discharge, and a feeling of blockage in the ear. This randomized controlled study was conducted to compare two commonly used topical treatments for otomycosis: clotrimazole ear drops and 2% salicylic acid ear drops. A total of 60 patients diagnosed with otomycosis were enrolled and were randomly assigned in equal numbers to one of the two treatment groups. One group received clotrimazole drops three times daily for two weeks, while the other group received 2% salicylic acid drops at the same frequency and for the same duration. Patients were assessed at the start of treatment and again after two weeks. The main outcome measure was relief of ear blockage, which reflected improvement in canal patency after treatment. It was hypothesized that topical clotrimazole would be more effective than 2% salicylic acid in clearing ear blockage and improving short-term clinical recovery in patients with otomycosis. This study was conducted to provide evidence for selecting an effective, practical, and affordable topical treatment for routine clinical use.
Conditions: Otomycosis
Interventions: clotrimazole, 2% Salicylic Acid
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