Blood Flow Restriction Parameters and Lower Limb Function in Older Adults With Dynapenia
Summary
NIH registered clinical trial NCT07534150, a two-phase study examining limb occlusion pressure (LOP) measurements and muscle electrophysiology in older adults with dynapenia. Year one collects baseline LOP data and influencing factors; year two uses high-density surface electromyography to analyze motor unit recruitment under varying BFR pressures. No regulatory obligations imposed.
What changed
NIH registered clinical trial NCT07534150, a prospective observational and physiological study in older adults with dynapenia. Year one collects limb occlusion pressure measurements alongside demographic and physiological characteristics including body composition, muscle mass, and functional performance. Year two employs high-density surface electromyography to analyze motor unit recruitment patterns under varying blood flow restriction pressures.
This registry entry imposes no compliance obligations. Healthcare providers and clinical investigators conducting related research may reference the study methodology for protocol design considerations. The study registration is informational and does not create regulatory requirements for the healthcare or research community.
Archived snapshot
Apr 17, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Blood Flow Restriction Parameters and Lower Limb Function in Older Adults With Dynapenia
N/A NCT07534150 Kind: NA Apr 16, 2026
Abstract
The objective of the first year is to collect limb occlusion pressure (LOP) measurements in older adults with varying levels of muscle health, which will serve as foundational data for subsequent investigations on blood flow restriction (BFR) combined with resistance training in individuals with dynapenia. This phase aims to examine LOP values and their potential influencing factors, including demographic and physiological characteristics such as age, height, body weight, blood pressure, waist circumference, body fat percentage, medical history of chronic diseases, and habitual physical activity. Muscle-related assessments will include skeletal muscle mass, thigh and calf circumference, handgrip strength, and lower limb muscle strength. Functional performance will be evaluated using the five-times sit-to-stand test and the SARC-F questionnaire for sarcopenia risk screening. LOP of the lower limbs will be measured using a BFR cuff system combined with a laboratory-developed blood flow detection device. The study will further investigate whether LOP values are associated with the aforementioned factors.
The objective of the second year is to utilize high-density surface electromyography (dEMG) to analyze the electrophysiological characteristics of muscle contraction in individuals with sarcopenia under varying BFR pressures and resistance intensities. This includes examining motor unit recruitment patterns and recruitment thresholds, with the goal of identifying effective a...
Conditions: Dynapenia
Interventions: Blood Flow Restriction, Conventional Resistance Training
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