Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
Summary
The European Patent Office published patent application EP4225447A1 for Vertex Pharmaceuticals Incorporated, covering CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) modulator compounds. The application was published April 1, 2026 with IPC classifications in pharmaceutical compositions (A61P 43/00, A61K 31/519) and specific chemical compounds (C07D 515/04). The patent lists 24 named inventors and designates all EPO contracting states.
What changed
The EPO published patent application EP4225447A1 for Vertex Pharmaceuticals covering CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) modulator compounds and their use in treating cystic fibrosis. The application includes 24 named inventors and covers pharmaceutical compositions containing the disclosed compounds with IPC classifications indicating therapeutic applications.
For pharmaceutical companies and biotech firms developing cystic fibrosis treatments, this publication establishes a priority date and公开 visibility for Vertex's intellectual property around CFTR modulators. Generic manufacturers and competing developers should monitor examination proceedings to assess claim scope and potential invalidity grounds.
What to do next
- Monitor for patent grant and examination proceedings
- Review IP strategy for CFTR modulator compounds in Europe
- Track potential oppositions from generic manufacturers
Archived snapshot
Apr 8, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
Publication EP4225447A1 Kind: A1 Apr 01, 2026
Applicants
Vertex Pharmaceuticals Incorporated
Inventors
MCCARTNEY, Jason, ABELA, Alexander Russell, ABRAHAM, Sunny, ANDERSON, Corey Don, ARUMUGAM, Vijayalaksmi, CHAU, Jaclyn, CLEMENS, Jeremy, CLEVELAND, Thomas, COON, Timothy Richard, DINH, Andrew, DWIGHT, Timothy A., FANNING, Lev Tyler Dewey, FRIEMAN, Bryan A., GROOTENHUIS, Peter, HADIDA RUAH, Sara Sabina, ISHIHARA, Yoshihiro, KRENITSKY, Paul, MILLER, Mark Thomas, PIERRE, Fabrice, SILINA, Alina, TRAN, Joe A., VALDEZ, Lino, ZHOU, Jinglan
IPC Classifications
A61P 43/00 20060101AFI20220415BHEP C07D 515/04 20060101ALI20220415BHEP A61K 31/519 20060101ALI20220415BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
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