The United States Patent and Trademark Office (USPTO) has issued patent US12583860B2 to Apotex Inc. This patent details novel processes for preparing specific crystalline forms of active pharmaceutical ingredients (APIs). The described methods involve mixing a solid API with a pharmaceutically acceptable high-boiling liquid or solid in the presence of solvent vapour, and specifically mentions the use of rotary apparatus like rotary cone dryers.

This patent grant represents a new intellectual property right for Apotex Inc. in the area of pharmaceutical manufacturing. Companies involved in the synthesis and formulation of APIs, particularly those seeking to control crystalline forms for improved stability, bioavailability, or manufacturing efficiency, should be aware of this granted patent. While this is a patent grant and not a regulatory rule imposing direct compliance obligations, it may impact freedom to operate for competitors in this specific area of chemical process development.