Changeflow GovPing Pharma & Drug Safety USPTO Patent Grant for GRP78 Antibodies in Canc...
Routine Notice Added Final

USPTO Patent Grant for GRP78 Antibodies in Cancer Treatment

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Published March 17th, 2026
Detected March 22nd, 2026
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Summary

The USPTO has granted a patent (US12577301B2) to Rutgers, The State University of New Jersey for GRP78-binding antibodies. These antibodies are intended for the detection, diagnosis, and therapeutic treatment of cancers.

What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12577301B2 for isolated or recombinant EphA5 or GRP78 targeting antibodies. The patent, assigned to Rutgers, The State University of New Jersey, covers the use of these antibodies in the detection, diagnosis, and therapeutic treatment of human diseases, particularly cancer. It also includes a method for rapidly identifying antibodies or antibody fragments for cancer treatment.

This patent grant represents a new intellectual property asset in the field of cancer therapeutics and diagnostics. While not a regulatory rule imposing obligations on other entities, it signifies innovation and potential future commercialization in the pharmaceutical sector. Companies involved in cancer research or antibody development may wish to be aware of this patent for competitive intelligence and potential licensing opportunities.

Source document (simplified)

← USPTO Patent Grants

GRP78-binding antibodies and use thereof in detecting or neutralizing GRP78

Grant US12577301B2 Kind: B2 Mar 17, 2026

Assignee

Rutgers, The State University of New Jersey

Inventors

Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R.M. Bradbury

Abstract

Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.

CPC Classifications

C07K 16/18 A61K 39/3955

Filing Date

2024-07-12

Application No.

18771877

Claims

31

View original document →

Named provisions

GRP78-binding antibodies and use thereof in detecting or neutralizing GRP78

Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
USPTO
Published
March 17th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12577301B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Activity scope
Cancer Detection Cancer Treatment Antibody Development
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Research & Development
Topics
Cancer Research Biotechnology

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