USPTO Patent Grant for GRP78 Antibodies in Cancer Treatment
Summary
The USPTO has granted a patent (US12577301B2) to Rutgers, The State University of New Jersey for GRP78-binding antibodies. These antibodies are intended for the detection, diagnosis, and therapeutic treatment of cancers.
What changed
The United States Patent and Trademark Office (USPTO) has issued patent US12577301B2 for isolated or recombinant EphA5 or GRP78 targeting antibodies. The patent, assigned to Rutgers, The State University of New Jersey, covers the use of these antibodies in the detection, diagnosis, and therapeutic treatment of human diseases, particularly cancer. It also includes a method for rapidly identifying antibodies or antibody fragments for cancer treatment.
This patent grant represents a new intellectual property asset in the field of cancer therapeutics and diagnostics. While not a regulatory rule imposing obligations on other entities, it signifies innovation and potential future commercialization in the pharmaceutical sector. Companies involved in cancer research or antibody development may wish to be aware of this patent for competitive intelligence and potential licensing opportunities.
Source document (simplified)
GRP78-binding antibodies and use thereof in detecting or neutralizing GRP78
Grant US12577301B2 Kind: B2 Mar 17, 2026
Assignee
Rutgers, The State University of New Jersey
Inventors
Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R.M. Bradbury
Abstract
Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
CPC Classifications
C07K 16/18 A61K 39/3955
Filing Date
2024-07-12
Application No.
18771877
Claims
31
Named provisions
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