GRP78-binding antibodies and use thereof in detecting or neutralizing GRP78
Grant
US12577301B2
Kind: B2
Mar 17, 2026
Assignee
Rutgers, The State University of New Jersey
Inventors
Renata Pasqualini, Wadih Arap, Fernanda I. Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R.M. Bradbury
Abstract
Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
CPC Classifications
C07K 16/18
A61K 39/3955
Filing Date
2024-07-12
Application No.
18771877
Claims
31