Method and System for Fully Continuous-Flow Preparation of Nitroimidazole Antimicrobial Agent
Summary
USPTO published patent application US20260098016A1 for a fully continuous-flow method of synthesizing nitroimidazole antimicrobial agents. The method uses glyoxal aqueous solution, acetaldehyde aqueous solution, and ammonium hydroxide as raw materials through multi-step chemical reactions. Inventors include Fener Chen, Minjie Liu, Li Wan, Yajiao Zhang, Xingpeng Cai, and Zhisheng Yang. The system includes micromixers, microreactors, back pressure valves, gas-liquid separators, and online solvent switching units.
What changed
USPTO published patent application US20260098016A1 for a continuous-flow synthesis method of nitroimidazole antimicrobial agents. The application discloses a fully automated system employing micromixers, microreactors, back pressure valves, gas-liquid separators, and online solvent switching units to produce nitroimidazole compounds with high purity from glyoxal, acetaldehyde, and ammonium hydroxide starting materials.
Pharmaceutical manufacturers and chemical process engineers should monitor this application's progress toward grant. If issued, the patent would cover the continuous-flow synthesis methodology for nitroimidazole antimicrobial compounds, potentially affecting production methods in pharmaceutical manufacturing. Inventors and assignees should track office actions and response deadlines.
What to do next
- Monitor for patent grant or office action response deadlines
- Review claims for potential infringement concerns
- Assess applicability to current pharmaceutical synthesis operations
Archived snapshot
Apr 9, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
METHOD AND SYSTEM FOR FULLY CONTINUOUS-FLOW PREPARATION OF NITROIMIDAZOLE ANTIMICROBIAL AGENT
Application US20260098016A1 Kind: A1 Apr 09, 2026
Inventors
Fener CHEN, Minjie LIU, Li WAN, Yajiao ZHANG, Xingpeng CAI, Zhisheng YANG
Abstract
A method for fully continuous-flow preparation of a nitroimidazole antimicrobial agent using a fully continuous-flow system is provided herein. The method adopts a raw material of a glyoxal aqueous solution, an acetaldehyde aqueous solution and an ammonium hydroxide solution followed by multi-step chemical reactions and continuous post-treatments to yield a nitroimidazole antimicrobial agent with a high purity. The fully continuous-flow system for implementing the method includes a plurality of micromixers, a plurality of microreactors, a plurality of back pressure valves, a plurality of gas-liquid separators, a first plurality of online solvent switching units and a feed unit.
CPC Classifications
C07D 233/92 B01J 19/0006 B01J 19/0093 B01J 2219/00094 B01J 2219/00101 B01J 2219/00162 B01J 2219/0086 B01J 2219/00867 B01J 2219/00873 B01J 2219/00889 B01J 2219/00963
Filing Date
2025-12-11
Application No.
19417229
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