Liver-Specific Viral Promoters for Gene Therapy
Summary
The European Patent Office granted uniQure IP B.V. Patent EP3884049A1 covering liver-specific viral promoters for gene therapy applications. The patent protects proprietary technology for liver-targeted gene therapy vectors developed by the inventors listed. Biotechnology and pharmaceutical companies developing liver-directed gene therapies should review this grant for licensing or freedom-to-operate considerations.
What changed
EPO granted Patent EP3884049A1 to uniQure IP B.V. covering liver-specific viral promoters and methods of using the same in gene therapy. The patent application (filed under IPC classifications C12N 15/11, C07K 14/755, C12N 15/79) names eight inventors including Lubelski, du Plessis, Liu, ter Brake, and others. The designation covers all standard EPO member states including AT, BE, CH, DE, ES, FR, GB, IT, NL, and others.\n\nThis patent grant affects companies developing AAV-based or other viral vector gene therapies targeting liver tissue. Freedom-to-operate analyses should incorporate this IP position. No immediate compliance actions are required, but companies in the gene therapy space should review their pipeline technologies against this newly granted patent claims to assess potential licensing needs or design-around strategies.
Source document (simplified)
LIVER-SPECIFIC VIRAL PROMOTERS AND METHODS OF USING THE SAME
Publication EP3884049A1 Kind: A1 Mar 25, 2026
Applicants
uniQure IP B.V.
Inventors
LUBELSKI, Jacek, DU PLESSIS, David Johannes Francois, LIU, Ying Pui, TER BRAKE, Olivier, IGLESIAS GONZALEZ, Juan Manuel, FRASER, Ross, ROBERTS, Michael
IPC Classifications
C12N 15/11 20060101AFI20200529BHEP C07K 14/755 20060101ALI20200529BHEP C12N 15/79 20060101ALI20200529BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Named provisions
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