Tricyclic Heteroaryl Compounds as Inhibitors of TYK2 and/or JAK1
Summary
The USPTO published patent application US20260098044A1 for tricyclic heteroaryl compounds that inhibit TYK2 and/or JAK1 activity. The compounds are directed toward treating skin, respiratory, ophthalmic, and rectal diseases, cancer, and neuroinflammation. Inventors include Stacey Shepard, Onur Atasoylu, Song Mei, and Jun Pan, with application number 19348390 filed October 2, 2025.
What changed
The USPTO published a new patent application covering tricyclic heteroaryl compounds designed to modulate TYK2 and JAK1 kinase activity. The compounds have potential therapeutic applications in skin disorders, respiratory conditions, ophthalmic diseases, rectal disorders, oncological conditions, and neuroinflammation.
For pharmaceutical companies and researchers in kinase inhibitor development, this patent application represents potential prior art that could affect freedom-to-operate considerations for competing TYK2 or JAK1 inhibitor programs. Competitors developing similar compounds should conduct patent landscape analysis to assess potential infringement risks.
What to do next
- Monitor for patent prosecution updates
- Review claims for freedom-to-operate analysis
Archived snapshot
Apr 11, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
TRICYCLIC HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2 AND/OR JAK1
Application US20260098044A1 Kind: A1 Apr 09, 2026
Inventors
Stacey Shepard, Onur Atasoylu, Song Mei, Jun Pan
Abstract
The present application provides tricyclic heteroaryl compounds that modulate the activity of the JAK1 and/or TYK2, which are useful in the treatment of various disorders and diseases, including skin, respiratory, ophthalmic, and rectal diseases and disorders, cancer, and neuroinflammation.
CPC Classifications
C07D 495/14 A61K 31/437 A61K 31/444 A61K 31/496 A61K 31/497 A61K 31/501 A61K 31/506 A61K 31/5377 C07D 519/00
Filing Date
2025-10-02
Application No.
19348390
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Source
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