Methods and Compositions for Designing and Selecting TinyRNAs to Maximize Target Cleavage

USPTO published patent application US20260098266A1 disclosing methods for designing and selecting tinyRNAs using guide RNA and Argonaute (AGO) molecules for gene expression regulation in biotherapeutic and diagnostic applications. The application covers engineered guide RNAs interacting with target nucleic acids for gene regulation purposes.

Pharmaceutical and biotechnology companies developing gene therapy products, diagnostics, or biotherapeutic applications should monitor this application through the examination process. If granted, the patent may affect IP strategy and freedom-to-operate analyses for entities working with tinyRNA and Argonaute technologies in gene expression applications.