Azabicyclo Chromenone Derivatives for RNA Splicing Modulation in Neurological Diseases
Summary
The European Patent Office published patent EP4192454A1, granted to Skyhawk Therapeutics, Inc., covering 6-(6-((8-azabicyclo[3.2.1]octan-3-yl)amino)-1,2,4-triazin-3-yl)-7-hydroxy-4H-chromen-4-one derivatives. The patent claims compositions and methods for modulating RNA splicing for the treatment of neurological diseases. The patent names three inventors and is designated across 38 European contracting states.
What changed
The EPO published European Patent Application EP4192454A1 for Skyhawk Therapeutics, covering azabicyclo chromenone derivatives that modulate RNA splicing. The compound compositions are directed toward treating neurological diseases. IPC classifications span heterocyclic compounds (C07D 451/04, C07D 498/08) and pharmaceutical preparations (A61K 31/53, A61K 31/439). The patent also covers uses for neurological conditions (A61P 25/00) and oncology (A61P 35/00).
Pharmaceutical companies developing RNA splicing modulators for neurological applications should conduct freedom-to-operate analyses before entering the European market. Companies with competing technologies in this therapeutic space should evaluate potential patent conflicts. The patent provides exclusive rights in 38 EPO contracting states including all major EU markets, with validity running from the filing date.
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Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
6-(6-((8-AZABICYCLO[3.2.1]OCTAN-3- YL)AMINO)-1,2,4-TRIAZIN-3-YL)-7-HYDROXY-4H-CHROMEN-4-ONE DERIVATIVES FOR MODULATING SPLICING FOR THE TREATMENT OF NEUROLOGICAL DISEASES
Publication EP4192454A1 Kind: A1 Mar 25, 2026
Applicants
Skyhawk Therapeutics, Inc.
Inventors
LUZZIO, Michael, LUCAS, Brian, WANG, Tiansheng
IPC Classifications
C07D 451/04 20060101AFI20251202BHEP C07D 498/08 20060101ALI20251202BHEP A61K 31/53 20060101ALI20251202BHEP A61K 31/439 20060101ALI20251202BHEP A61P 25/00 20060101ALI20251202BHEP A61P 35/00 20060101ALI20251202BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
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