Roche UBE3A Angelman Syndrome Oligonucleotide Patent Granted
Summary
USPTO granted patent US12596118B2 to Hoffmann-La Roche Inc. covering oligonucleotides capable of inducing paternal UBE3A expression for treatment of Angelman syndrome. The patent, listing 9 inventors, contains 30 claims targeting the SNHG14 long non-coding RNA downstream of SNORD109B. This is a pharmaceutical composition patent within the oligonucleotides therapeutic space.
What changed
USPTO granted patent US12596118B2 to Hoffmann-La Roche Inc. for oligonucleotides designed to induce expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in neurons. The compositions target the suppressor of the UBE3A paternal allele via hybridization to SNHG14 long non-coding RNA for treatment of Angelman syndrome. The patent application was filed July 2, 2025, under Application No. 19258035.
This patent grant strengthens Hoffmann-La Roche's intellectual property position in the oligonucleotide therapeutics space for rare neurological disorders. Competitors developing similar UBE3A expression modulators for Angelman syndrome may face freedom-to-operate challenges and potential licensing requirements. The patent provides 20-year exclusivity from the filing date for the pharmaceutical compositions and associated treatment methods.
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Apr 7, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Oligonucleotides for inducing paternal UBE3A expression
Grant US12596118B2 Kind: B2 Apr 07, 2026
Assignee
Hoffmann-La Roche Inc.
Inventors
Veronica Costa, Maj Hedtjärn, Marius Hoener, Ravi Jagasia, Mads Aaboe Jensen, Christoph Patsch, Lykke Pedersen, Søren Vestergaard Rasmussen
Abstract
The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.
CPC Classifications
C12N 15/11 C12N 15/111 C12N 15/113 C12N 15/1137 C12N 2310/11 C12N 2310/315 C12N 2310/321 C12N 2310/322 C12N 2310/3231 C12N 2310/3341 C12N 2310/341 C12N 2310/346 A61K 31/7088
Filing Date
2025-07-02
Application No.
19258035
Claims
30
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