Changeflow GovPing Pharma & Drug Safety BCD Gene Therapy Patent Grant
Routine Notice Added Final

BCD Gene Therapy Patent Grant

Favicon for changeflow.com ChangeBridge: Patent Grants - Biotech (C12N)
Published March 31st, 2026
Detected March 31st, 2026
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Summary

The USPTO granted Patent US12590320B2 to Reflection Biotechnologies Limited for gene therapy methods treating Bietti's Crystalline Dystrophy (BCD). The patent covers vectors delivering CYP4V2 protein to retinal pigment epithelial cells. This represents a routine patent grant establishing intellectual property rights for a biotechnology invention.

What changed

The USPTO issued B2 Patent US12590320B2 to Reflection Biotechnologies Limited, covering methods for treating ocular diseases including Bietti's Crystalline Dystrophy using gene therapy vectors that deliver CYP4V2 protein to retinal cells. The patent (CPC: C12N 15/86) was filed July 31, 2018, under Application No. 16635863, with 34 claims granted.

This is a routine patent grant notification establishing intellectual property protection. No compliance actions or deadlines apply. Pharmaceutical companies and healthcare providers developing gene therapies for inherited retinal diseases should note this patent when designing similar programs to avoid infringement. Legal and R&D teams should review the claims scope for potential licensing discussions.

Source document (simplified)

← USPTO Patent Grants

Cellular models of and therapies for ocular diseases

Grant US12590320B2 Kind: B2 Mar 31, 2026

Assignee

Reflection Biotechnologies Limited

Inventors

Richard R. Yang, Stephen H Tsang

Abstract

Provided herein are methods for treating or preventing diseases of the eye such as Bietti's Crystalline Dystrophy (BCD) using, for example, vectors for delivering a gene encoding a CYP4V2 protein to the retina (for example, to the retinal pigment epithelial (RPE) cells) or using cells comprising such vectors.

CPC Classifications

C12N 15/86

Filing Date

2018-07-31

Application No.

16635863

Claims

34

View original document →

Source

Analysis generated by AI. Source diff and links are from the original.

Classification

Agency
USPTO
Published
March 31st, 2026
Instrument
Notice
Legal weight
Binding
Stage
Final
Change scope
Minor
Document ID
US12590320B2

Who this affects

Applies to
Pharmaceutical companies Healthcare providers Drug manufacturers
Industry sector
3254 Pharmaceutical Manufacturing 3254.1 Biotechnology
Geographic scope
United States US

Taxonomy

Primary area
Intellectual Property
Operational domain
Intellectual Property
Topics
Healthcare Biotechnology Pharmaceuticals

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