Changeflow GovPing Pharma & Drug Safety USPTO Patent Grant: PD-L1 Antagonist Compound
Routine Notice Added Final

USPTO Patent Grant: PD-L1 Antagonist Compound

Favicon for changeflow.com ChangeBridge: Patent Grants - Organic Chemistry (C07D)
Published March 24th, 2026
Detected March 24th, 2026
Email

Summary

The USPTO has granted a patent (US12583839B2) to ADLAI NORTYE BIOPHARMA CO., LTD. for a PD-L1 antagonist compound and its pharmaceutical composition. The patent covers compounds of Formula (I) and their use in treating immune-related disorders.

What changed

The United States Patent and Trademark Office (USPTO) has issued patent US12583839B2, granting exclusive rights to ADLAI NORTYE BIOPHARMA CO., LTD. for a novel PD-L1 antagonist compound. The patent, which includes a compound of Formula (I), a pharmaceutical composition thereof, and a method for treating immune-related disorders, was filed on December 22, 2020, and granted on March 24, 2026. This grant signifies a new intellectual property asset for the assignee in the field of immunology and drug development.

This patent grant primarily impacts the assignee by providing market exclusivity for the patented compound. For other entities in the pharmaceutical and biotechnology sectors, this represents a new patent to consider in their freedom-to-operate analyses and competitive intelligence. While this is a patent grant and not a regulatory rule with direct compliance obligations for other companies, it is crucial for R&D, legal, and business development teams to be aware of this new intellectual property to avoid potential infringement claims and to inform their own drug development strategies.

Source document (simplified)

← USPTO Patent Grants

PD-L1 antagonist compound

Grant US12583839B2 Kind: B2 Mar 24, 2026

Assignee

ADLAI NORTYE BIOPHARMA CO., LTD.

Inventors

Zhiyong Yu, Pan Li, Beidi Xu, Yu Zhou, Wei Pang, Qiaodong Wen, Yongqiang Shi, Zhao Sun, Meng Lv

Abstract

Provided are a compound of Formula (I) and a pharmaceutical composition thereof, as well as a method for using the compounds of Formula (I) to prevent and/or treat immune-related disorders.

CPC Classifications

C07D 403/12 C07D 401/12 C07D 401/14 C07D 403/10 C07D 403/14 C07D 405/14

Filing Date

2020-12-22

Application No.

17780979

Claims

19

View original document →

Named provisions

Assignee Inventors Abstract CPC Classifications Filing Date Application No. Claims

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12583839B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Intellectual Property
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Intellectual Property Drug Development

Get Pharma & Drug Safety alerts

Weekly digest. AI-summarized, no noise.

Free. Unsubscribe anytime.

Get alerts for this source

We'll email you when ChangeBridge: Patent Grants - Organic Chemistry (C07D) publishes new changes.

Optional. Personalizes your daily digest.

Free. Unsubscribe anytime.