Changeflow GovPing Pharma & Drug Safety USPTO Patent Grant US12583844B2: Hydantoin MMP ...
Routine Notice Added Final

USPTO Patent Grant US12583844B2: Hydantoin MMP Inhibitors

Favicon for changeflow.com ChangeBridge: Patent Grants - Organic Chemistry (C07D)
Published March 24th, 2026
Detected March 24th, 2026
Email

Summary

The USPTO has granted patent US12583844B2 to Foresee Pharmaceuticals USA, Inc. for hydantoin-based compounds that act as inhibitors of matrix metalloproteinases (MMPs), particularly MMP-12. The patent covers compositions and methods for treating various diseases mediated by MMP-12.

What changed

USPTO Patent Grant US12583844B2, titled 'Hydantoin MMP inhibitors for disease treatment,' has been issued to Foresee Pharmaceuticals USA, Inc. The patent covers novel hydantoin-based compounds designed to inhibit matrix metalloproteinases (MMPs), with a specific focus on MMP-12. The claims extend to compositions containing these inhibitors and methods for their use in treating a range of diseases, including inflammatory conditions, respiratory diseases, fibrotic disorders, arthritis, cancer, and cardiovascular diseases.

This patent grant signifies the protection of intellectual property related to new therapeutic agents. While it does not impose direct compliance obligations on other entities, it is relevant for pharmaceutical companies and researchers in the organic chemistry and drug development space. Companies developing or researching MMP inhibitors should be aware of this patent to avoid potential infringement and to inform their own R&D strategies.

Source document (simplified)

← USPTO Patent Grants

Matrix metalloproteinase (MMP) inhibitors and methods of use thereof

Grant US12583844B2 Kind: B2 Mar 24, 2026

Assignee

Foresee Pharmaceuticals USA, Inc.

Inventors

Wenjin Yang, Kai-Wei Chang

Abstract

Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

CPC Classifications

C07D 405/14 C07D 409/14 C07D 401/14 C07D 403/14

Filing Date

2020-11-13

Application No.

17755983

Claims

16

View original document →

Named provisions

Matrix metalloproteinase (MMP) inhibitors and methods of use thereof

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Notice
Legal weight
Non-binding
Stage
Final
Change scope
Minor
Document ID
US12583844B2

Who this affects

Applies to
Drug manufacturers Pharmaceutical companies
Industry sector
3254 Pharmaceutical Manufacturing
Activity scope
Drug Development Intellectual Property Management
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Research & Development
Topics
Medical Devices Intellectual Property

Get Pharma & Drug Safety alerts

Weekly digest. AI-summarized, no noise.

Free. Unsubscribe anytime.

Get alerts for this source

We'll email you when ChangeBridge: Patent Grants - Organic Chemistry (C07D) publishes new changes.

Optional. Personalizes your daily digest.

Free. Unsubscribe anytime.