USPTO Patent US12582708B2: Recombinant Influenza Viruses
Summary
The USPTO has granted patent US12582708B2 for a novel recombinant influenza virus engineered to express an interferon-beta gene. This patent, assigned to I.D.BIO., aims to enhance antiviral action by introducing a foreign gene into the NS1 gene of the influenza virus.
What changed
The United States Patent and Trademark Office (USPTO) has granted patent US12582708B2, titled 'Recombinant influenza viruses comprising truncated NS1 fusion proteins,' to I.D.BIO. The patent describes a novel recombinant influenza virus that incorporates a foreign interferon-beta gene into the NS1 gene. This modification is intended to suppress the host immune system and induce an antiviral action, with the interferon-beta gene functioning independently of the NS1 protein.
This patent grant represents a new intellectual property development in the field of virology and vaccine research. While it does not impose direct compliance obligations on regulated entities, it signifies a technological advancement that may influence future research and development strategies for influenza treatments and vaccines. Companies operating in the biotechnology and pharmaceutical sectors should be aware of this patent as it pertains to recombinant virus technology and antiviral gene expression.
Source document (simplified)
Recombinant influenza viruses comprising truncated NS1 fusion proteins
Grant US12582708B2 Kind: B2 Mar 24, 2026
Assignee
I.D.BIO.
Inventors
Young-Jae Si, Hyuk-Il Kwon, Yeo-Jeong Choi
Abstract
The present disclosure relates to a novel recombinant influenza virus, in which an interferon-beta gene, which is a foreign gene associated with an antiviral action, is introduced to an NS1 gene which is an influenza virus gene that is expressed first in the host to suppress the host immune system when infected with the influenza virus, and, in contrast to existing research, the interferon-beta is separated from the NS1 protein to carry out an intrinsic function of interferon-beta of inducing an antiviral action.
CPC Classifications
A61K 39/145 C12N 2760/16111 C12N 2760/16122
Filing Date
2020-02-10
Application No.
17431070
Claims
6
Named provisions
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