Patent for SGLT Inhibitor Synthesis Intermediate

ChangeBridge: Patent Apps - Organic Chemistry (C07D)

Published November 21st, 2025

Detected March 26th, 2026

Summary

The USPTO has published a patent application for a crystalline form of an intermediate useful in the synthesis of SGLT inhibitors. The application details a method to improve purification efficiency and minimize related substances in the final product, potentially increasing yield.

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What changed

This document is a patent application (US20260085065A1) filed by Youn Jung Yoon and Hee Kyoon Yoon with the USPTO. It describes a novel crystalline form of an intermediate for synthesizing SGLT inhibitors, aiming to resolve purification difficulties, achieve higher quality standards for related substances with fewer purification steps, and solve quality control issues in continuous synthesis processes. The application also claims an increased yield for the diphenylmethane derivative.

As this is a patent application, it does not impose direct compliance obligations on regulated entities. However, companies involved in the research, development, or manufacturing of SGLT inhibitors may find this disclosure relevant for their intellectual property strategies and process optimization efforts. The filing date was November 21, 2025.

Source document (simplified)

← USPTO Patent Applications

CRYSTALLINE FORM OF SGLT INHIBITOR

Application US20260085065A1 Kind: A1 Mar 26, 2026

Inventors

Youn Jung YOON, Hee Kyoon YOON

Abstract

An intermediate useful for the synthesis of an SGLT inhibitor and a method for preparing an SGLT inhibitor are provided. By employing an intermediate having Chemical Formula 5, the difficulty of purification with existing processes can be solved, the quality requirements for related substances can be achieved with only one purification step, and the quality control problem in each step can be solved by performing several steps in situ. A method for synthesizing a compound of Chemical Formula 1 by using a compound of Chemical Formula 5 enables purification in an earlier step, thereby solving the problems of existing synthesis processes, in which the quality requirements for related substances were difficult to control step-by-step due to a continuous process, thereby minimizing the amount of related substances in the final product. In addition, the yield of a diphenylmethane derivative according to Chemical Formula 1 is increased.