NURIX BTK Degrading Compounds, 36 Claims, Apr 14
Summary
The USPTO granted Patent US12600732B2 to NURIX THERAPEUTICS, INC. on April 14, 2026. The patent covers 36 claims for bifunctional compounds that degrade BTK via the ubiquitin proteolytic pathway, along with pharmaceutical compositions and methods of treatment for various diseases, conditions, or disorders.
What changed
USPTO granted Patent US12600732B2 to NURIX THERAPEUTICS, INC. covering 36 claims for bifunctional compounds designed to degrade BTK (Bruton's tyrosine kinase) through the ubiquitin proteolytic pathway. The patent also covers pharmaceutical compositions comprising these compounds and methods of using them to treat various diseases, conditions, or disorders.
For pharmaceutical and biotechnology companies, this patent establishes NURIX's intellectual property rights in the BTK degradation space via PROTAC technology. Competitors developing similar bifunctional compounds targeting BTK through ubiquitin-mediated degradation should assess freedom-to-operate implications and potential licensing needs.
What to do next
- Monitor patent portfolio for competitive analysis
- Review patent claims for freedom-to-operate assessment
Archived snapshot
Apr 15, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
Grant US12600732B2 Kind: B2 Apr 14, 2026
Assignee
NURIX THERAPEUTICS, INC.
Inventors
Aileen Kelly, Arthur T. Sands
Abstract
This disclosure relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The description also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
CPC Classifications
C07D 487/04 A61P 35/00 A61P 19/00 A61P 37/00 A61K 31/40 A61K 31/403 A61K 31/4035
Filing Date
2023-03-10
Application No.
18120341
Claims
36
Named provisions
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