ONO Pharmaceutical ABHD6 Antagonist Patent US12600730B2
Summary
USPTO granted Patent US12600730B2 to ONO Pharmaceutical Co., Ltd. on April 14, 2026, covering substituted cyclopenta[c]pyrrole compounds as ABHD6 antagonists for pharmaceutical use. The patent includes 18 claims for compounds useful in preventing or treating diseases associated with ABHD6 enzyme inhibition. The application was filed on April 8, 2024.
What changed
USPTO granted patent protection for ONO Pharmaceutical's ABHD6 antagonist compounds (substituted cyclopenta[c]pyrroles) with 18 claims covering the pharmaceutical compositions and methods of use. The patent claims priority from Application No. 18629648 filed April 8, 2024.
For pharmaceutical manufacturers and biotech companies developing metabolic or neurological therapeutics targeting the ABHD6 enzyme pathway, this patent establishes prior art and may necessitate licensing negotiations or alternative compound design strategies to avoid infringement.
What to do next
- Monitor patent portfolio for potential licensing opportunities
- Review freedom-to-operate for ABHD6 inhibitor development programs
Archived snapshot
Apr 15, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Substituted cyclopenta[c]pyrroles as ABHD6 antagonists
Grant US12600730B2 Kind: B2 Apr 14, 2026
Assignee
ONO PHARMACEUTICAL CO., LTD.
Inventors
Atsushi Yoshida, Ryuichi Hyakutake, Nozomu Nagashima, Ryosuke Misu, Shohei Mori
Abstract
A drug is provided, which contains, as an active ingredient, a compound having ABHD6 inhibitory activity in prevention and/or treatment of a disease associated with ABHD6. A compound of formula (I-A) or a pharmaceutically acceptable salt thereof has ABHD6 inhibitory activity and therefore is useful as a pharmaceutical ingredient having potent ABHD6 inhibitory activity in the prevention and/or treatment of a disease associated with ABHD6:
in which all symbols represent the same meaning as the symbols described in the specification.
CPC Classifications
A61K 31/403 C07D 209/52
Filing Date
2024-04-08
Application No.
18629648
Claims
18
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Source
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