NSAID Conjugate Anti-Inflammatory Compounds Via Microwave Synthesis

← USPTO Patent Applications

SYNTHESIS OF NSAID CONJUGATES AS ANTI-INFLAMMATORY AGENTS USING THE MOLECULAR HYBRIDIZATION

Application US20260098019A1 Kind: A1 Apr 09, 2026

Inventors

Siva PANDA

Abstract

Described are synthetic compounds having anti-inflammatory properties and optionally analgesic properties. These compounds are derivatives of FDA-approved anti-inflammatory, such as ibuprofen and indomethacin, and can be formed using reactions under microwave irradiation. Generally, the compounds contains a moiety of the parent drug, a triazolyl heterocycle, and a substituted or unsubstituted aryl group. In some forms, the compounds show anti-inflammatory properties and optionally analgesic properties with similar or higher efficiencies compared with their respective parent drugs, with additional advantages including no or reduced adverse effects (e.g., without ulcerogenic liability in the gastric) and/or selective inhibition of COX-2 over COX-1. Pharmaceutical compositions suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating an inflammatory disease or disorder in a subject are also disclosed.

CPC Classifications

C07D 249/06 A61K 31/4192 A61K 45/06 A61P 29/00 C07D 403/12

Filing Date

2023-10-09

Application No.

19112976

View original document →