Novel synthetic routes for macrocyclic heterocycle manufacturing
Summary
USPTO published patent application US20260092066A1 on April 2, 2026, disclosing novel synthetic methods for preparing macrocyclic heterocycle intermediates. The application (filed June 18, 2025, Application No. 19242506) covers efficient methods for synthesizing key intermediates in the preparation of Compound (I) with broad substituent applicability.
What changed
USPTO published patent application US20260092066A1 disclosing novel synthetic routes for macrocyclic heterocycle manufacturing. The application covers methods for preparing key intermediates in the synthesis of a complex heterocyclic compound (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one. The methods are described as highly efficient and broadly applicable across various substituent groups.
This patent application has no immediate compliance requirements or deadlines for third parties. Parties interested in the technology or seeking to design around the claims should review the application claims upon publication. Inventors listed include Nicolas Cuniere, Yu Fan, Sergei Kolotuchin, Subha Mukherjee, Eric M. Simmons, and others (14 total).
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
Application US20260092066A1 Kind: A1 Apr 02, 2026
Inventors
Nicolas CUNIERE, Yu FAN, Sergei KOLOTUCHIN, Subha MUKHERJEE, Eric M. SIMMONS, Amarjit SINGH, Carolyn S. WEI, Yi XIAO, Changxia YUAN, Bin ZHENG, Simon Albert WAGSCHAL, Diego Fernando Domenico BROGGINI, Duy Chi Trung CAO, Kostiantyn CHERNICHENKO, Sebastien Francois Emmanuel LEMAIRE, Cyril Ben HAIM
Abstract
Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
CPC Classifications
C07D 471/18 C07D 213/61 C07D 401/04
Filing Date
2025-06-18
Application No.
19242506
Named provisions
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