Novel Aromatic Ring Derivative Containing Amide Substitution as TYK2 Inhibitor
Summary
The USPTO has published patent application US20260098017A1 for a novel aromatic ring derivative containing amide substitution as a TYK2 inhibitor for treating inflammatory and autoimmune diseases including psoriasis, psoriatic arthritis, dermatitis, lupus, inflammatory bowel disease, and rheumatoid arthritis. The application was filed December 22, 2023, with inventors including Wenzhi Wang, Shuangyong Sun, and colleagues. The invention demonstrates therapeutic efficacy in psoriasis and asthma animal models with good druggability, stability, and safety profiles.
What changed
The USPTO published patent application US20260098017A1 for a novel aromatic ring derivative containing amide substitution used as a TYK2 inhibitor. The compound is designed to treat inflammatory and autoimmune diseases such as psoriasis, psoriatic arthritis, dermatitis, lupus erythematosus, inflammatory bowel disease, hidradenitis suppurativa, rheumatoid arthritis, and uveitis.
Pharmaceutical companies developing TYK2 inhibitors or treatments for the specified inflammatory conditions should review the pending claims to assess freedom-to-operate implications. Research institutions may benefit from monitoring the prosecution history for insights into structural-activity relationships and potential licensing opportunities.
What to do next
- Monitor for patent grant and claim scope
- Evaluate freedom to operate for TYK2 inhibitor programs
- Review patent claims for overlap with existing drug pipelines
Archived snapshot
Apr 9, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
NOVEL AROMATIC RING DERIVATIVE CONTAINING AMIDE SUBSTITUTION AND USE THEREOF
Application US20260098017A1 Kind: A1 Apr 09, 2026
Inventors
Wenzhi WANG, Shuangyong SUN, Chenhui YAO, Jiali AN, Jie ZHANG, Dengke LIU, Kunying HAN, Ruina WANG
Abstract
The present invention belongs to the technical field of medicine, and in particular relates to a novel aromatic ring derivative containing an amide substitution or a pharmaceutically acceptable salt thereof. The diseases comprise, but are not limited to, inflammatory or autoimmune diseases such as psoriasis, psoriatic arthritis, dermatitis, lupus erythematosus, inflammatory bowel disease, hidradenitis suppurativa, rheumatoid arthritis, and uveitis. The structure of the compound of formula I is as described in the claims and the description. The aromatic ring derivative containing an amide substitution provided in the present invention is used as a novel TYK2 inhibitor, has a good TYK2 inhibitory effect, has a good therapeutic effect in an in vivo model of psoriasis and asthma animals, and has good druggability, high stability and good safety.
CPC Classifications
C07D 237/24 A61K 31/44 A61K 31/4439 A61K 31/444 A61K 31/50 A61K 31/501 A61K 31/506 A61P 11/06 A61P 17/06 C07B 59/002 C07D 213/82 C07D 401/12 C07D 403/12
Filing Date
2023-12-22
Application No.
19142338
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