Tetrahydroquinoline Compounds As Antitumor Agents

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Tetrahydroquinoline Compounds As Antitumor Agents

Application US20260097029A1 Kind: A1 Apr 09, 2026

Inventors

Sandro COSCONATI, Stefano TOMASSI, Salvatore DI MARO, Hilda Amelia PICKETT

Abstract

The invention relates to a tetrahydroquinoline compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein A is (C3-C7)cycloalkyl; (C3-C7)heterocycloalkyl comprising from 1 to 3 heteroatoms selected from O, N, and S; (C1-C7)alkyl, (C1-C7) heteroalkyl comprising from 1 to 3 heteroatoms selected from O, N, and S; an optionally substituted phenyl ring or an optionally substituted (5-9)-membered heteroaromatic ring comprising from 1 to 3 heteroatoms selected from O, N, and S; R is H, (C1-C4) alkyl; (C1-C3)alkoxy(C1-C3)alkyl, (C3-C7)cycloalkyl; R1 and R2 are, independently from each other, selected from the group consisting of H, NO2, CN, halogen, (C1-C4)alkyl; (C2-C4)alkenyl; (C1-C4)alkoxy(C1-C4)alkyl, (C3-C7)cycloalkyl(C1-C4)alkyl, (C1-C4)alkyl substituted by a (5-9)-membered heteroaromatic ring comprising from 1 to 3 heteroatoms selected from O, N, and S, amino optionally substituted with bis(dimetilamino)methylene, pyridyl, trifluoromethyl-SO2—, (C1-C3)alkyl-SO2—, a group NH—CO—R3, wherein R3 is selected from the group consisting of benzyl, (C3-C7)cycloalkyl(C1-C4)alkyl, phenyl, vinyl, halogen-CH2—, (C1-C3)alkyl; a group NH—CH2—R4 wherein R4 is an optionally substituted phenyl ring or an optionally substituted (5-9)-membered heteroaromatic ring comprising from 1 to 3 heteroatoms selected from O, N and S; or R1 and R2 together form an optionally substituted aromatic ring comprising 6 carbon atoms. The tetrahydroquinoline compound of or a pharmaceutically acceptable salt thereof according to the invention is a disruptor of the FANCM/BTR interaction so as to hamper the FANCM localization to telomeres, preferably in the treatment of tumours.

CPC Classifications

A61K 31/4709 A61K 31/47 A61P 35/00 C07D 215/06 C07D 401/12 C07D 405/12

Filing Date

2023-09-22

Application No.

19112485

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