Multimeric T-Cell Modulatory Polypeptides and Methods of Use Thereof
Summary
The USPTO has published patent application US20260097127A1 for multimeric T-cell modulatory polypeptides comprising immunomodulatory polypeptides and epitope-presenting Wilms tumor peptides. The application, filed October 6, 2025, names Saso Cemerski, Rodolfo J. Chaparro, Ronald D. Seidel III, and John F. Ross as inventors. The published application covers methods for modulating T-cell activity and immune responses using the disclosed polypeptides.
What changed
The USPTO has published a patent application for multimeric T-cell modulatory polypeptides that combine immunomodulatory polypeptides with epitope-presenting Wilms tumor peptides. The application covers compositions and methods for modulating T-cell activity and immune responses in individuals.
For pharmaceutical and biotechnology companies, this published application represents prior art that may affect freedom-to-operate assessments for competing T-cell modulation technologies. Parties developing similar immunomodulatory or cancer immunotherapy approaches should review the claims to evaluate potential overlap with their own R&D programs.
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Apr 12, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Multimeric T-Cell Modulatory Polypeptides and Methods of Use Thereof
Application US20260097127A1 Kind: A1 Apr 09, 2026
Inventors
Saso Cemerski, Rodolfo J. Chaparro, Ronald D. Seidel, III, John F. Ross
Abstract
The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide and that comprise an epitope-presenting Wilms tumor peptide. A T-cell modulatory multimeric polypeptide is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.
CPC Classifications
A61K 47/646 A61K 39/001114 A61K 39/001153 A61K 47/642 A61K 47/6425 C07K 2319/30
Filing Date
2025-10-06
Application No.
19350474
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