Multifunctional drug delivery system for cancer treatment antibodies

ChangeBridge: Patent Apps - Therapeutics (A61P)

Published April 2nd, 2026

Detected April 2nd, 2026

Summary

USPTO published patent application US20260091125A1 for a multifunctional drug delivery system using inorganic core particles conjugated to antibodies for cancer treatment. The system delivers distinct immunoglobulins to cancerous cells and tissues outside the brain via four-linker architecture. Application filed January 12, 2023; granted Application No. 18865714.

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What changed

USPTO published patent application US20260091125A1 on April 2, 2026, for a multifunctional delivery system comprising an inorganic core particle conjugated through four linkers: two polymeric linkers to distinct immunoglobulins, a penetration enhancing moiety, and a capping spacer. The system targets cancerous cells and tissues outside the brain. CPC classifications include A61K 47/6929, A61K 47/62, A61K 47/6851, and A61P 35/00. Inventors include Revital Mandil Levin, Oshra Betzer, Yuval Sagiv, Adam Antebi, and Rachela Popovtzer.\n\nPatent applications do not create immediate compliance obligations. Pharmaceutical companies and drug manufacturers developing antibody-based cancer therapies should monitor this application's examination progress as it may indicate competitive landscape developments in targeted delivery technology. No action is required at this time.

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← USPTO Patent Applications

MULTIFUNCTIONAL DELIVERY SYSTEM AND USES THEREOF

Application US20260091125A1 Kind: A1 Apr 02, 2026

Inventors

Revital MANDIL LEVIN, Oshra BETZER, Yuval SAGIV, Adam ANTEBI, Rachela POPOVTZER

Abstract

The invention provides multifunctional system for the synchronized delivery of distinct immunoglobulins, in particular antibodies and antibody fragments to specific cancerous cells and tissues located outside of the brain. The multifunctional system is based on an inorganic core particle which is conjugated through a first polymeric linker to a first immunoglobulin; through a second polymeric linker to a second immunoglobulin; through a third polymeric linker to a penetration enhancing moiety; and to a fourth, monofunctional capping linker or spacer. Further provided are a process for preparation of the multifunctional system, pharmaceutical compositions comprising the multifunctional system and uses thereof in therapeutic and/or diagnostic methods.