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MAP Kinase Inhibitors Patent - Washington University

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Summary

The European Patent Office published patent EP4219489A2 for MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, methods of making, and methods of use thereof. Applicant is Washington University with six inventors including HOLTZMAN, ROMERO, GEROVAC, HAN, KEELER, and WU. The patent covers heterocyclic compounds classified under C07D with therapeutic applications including respiratory diseases (A61P 11/00), infections (A61P 31/00), and oncology (A61P 35/00).

What changed

EPO published patent application EP4219489A2 for MAP kinase inhibitor compounds and their methods of use. The patent, filed by Washington University (St. Louis, MO), covers heterocyclic compounds falling under IPC classifications C07D 401/12, C07D 405/12, C07D 407/14, C07D 409/14, C07D 413/12, C07D 417/14, and others. Designated states include all EPC contracting states (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR). The therapeutic indications covered include respiratory conditions (A61P 11/00), antimicrobial applications (A61P 31/00), and anticancer uses (A61P 35/00).

Pharmaceutical companies developing kinase inhibitor therapies should review this patent for freedom-to-operate considerations. Patent monitoring services should flag this publication for competitive intelligence tracking. The patent is now publicly available in the EPO register and provides protection for the disclosed compounds and methods in the designated contracting states.

What to do next

  1. Review patent EP4219489A2 for freedom-to-operate analysis if developing kinase inhibitor compounds
  2. Update IP portfolio monitoring to include this Washington University patent
  3. Consult patent counsel regarding potential licensing or opposition options

Archived snapshot

Apr 2, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← EPO Patent Bulletin

MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF

Publication EP4219489A2 Kind: A2 Mar 25, 2026

Applicants

Washington University

Inventors

HOLTZMAN, Michael, J., ROMERO, Arthur, G., GEROVAC, Benjamin, J., HAN, Zhenfu, KEELER, Shamus, P., WU, Kangyun

IPC Classifications

C07D 417/14 20060101AFI20231012BHEP C07D 401/12 20060101ALI20231012BHEP C07D 413/12 20060101ALI20231012BHEP C07D 213/75 20060101ALI20231012BHEP C07D 213/73 20060101ALI20231012BHEP C07F 7/10 20060101ALI20231012BHEP C07D 405/14 20060101ALI20231012BHEP C07D 405/12 20060101ALI20231012BHEP C07D 407/14 20060101ALI20231012BHEP C07D 409/14 20060101ALI20231012BHEP A61K 31/435 20060101ALI20231012BHEP A61P 11/00 20060101ALI20231012BHEP A61P 31/00 20060101ALI20231012BHEP A61P 35/00 20060101ALI20231012BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

View original document →

Named provisions

MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS METHODS OF MAKING METHODS OF USE THEREOF IPC Classifications C07D Series Therapeutic Applications A61P Series

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Last updated

Classification

Agency
EPO
Published
March 25th, 2026
Instrument
Notice
Legal weight
Binding
Stage
Final
Change scope
Minor
Document ID
EP4219489A2

Who this affects

Applies to
Pharmaceutical companies Educational institutions Drug manufacturers
Industry sector
3254 Pharmaceutical Manufacturing 6111 Higher Education 5411 Legal Services
Activity scope
Patent Grant Chemical Compound Protection Therapeutic Method Protection
Geographic scope
European Union EU

Taxonomy

Primary area
Pharmaceuticals
Operational domain
Legal
Topics
Intellectual Property Healthcare

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