MAP Kinase Inhibitors Patent - Washington University
Summary
The European Patent Office published patent EP4219489A2 for MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, methods of making, and methods of use thereof. Applicant is Washington University with six inventors including HOLTZMAN, ROMERO, GEROVAC, HAN, KEELER, and WU. The patent covers heterocyclic compounds classified under C07D with therapeutic applications including respiratory diseases (A61P 11/00), infections (A61P 31/00), and oncology (A61P 35/00).
What changed
EPO published patent application EP4219489A2 for MAP kinase inhibitor compounds and their methods of use. The patent, filed by Washington University (St. Louis, MO), covers heterocyclic compounds falling under IPC classifications C07D 401/12, C07D 405/12, C07D 407/14, C07D 409/14, C07D 413/12, C07D 417/14, and others. Designated states include all EPC contracting states (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR). The therapeutic indications covered include respiratory conditions (A61P 11/00), antimicrobial applications (A61P 31/00), and anticancer uses (A61P 35/00).
Pharmaceutical companies developing kinase inhibitor therapies should review this patent for freedom-to-operate considerations. Patent monitoring services should flag this publication for competitive intelligence tracking. The patent is now publicly available in the EPO register and provides protection for the disclosed compounds and methods in the designated contracting states.
What to do next
- Review patent EP4219489A2 for freedom-to-operate analysis if developing kinase inhibitor compounds
- Update IP portfolio monitoring to include this Washington University patent
- Consult patent counsel regarding potential licensing or opposition options
Archived snapshot
Apr 2, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF
Publication EP4219489A2 Kind: A2 Mar 25, 2026
Applicants
Washington University
Inventors
HOLTZMAN, Michael, J., ROMERO, Arthur, G., GEROVAC, Benjamin, J., HAN, Zhenfu, KEELER, Shamus, P., WU, Kangyun
IPC Classifications
C07D 417/14 20060101AFI20231012BHEP C07D 401/12 20060101ALI20231012BHEP C07D 413/12 20060101ALI20231012BHEP C07D 213/75 20060101ALI20231012BHEP C07D 213/73 20060101ALI20231012BHEP C07F 7/10 20060101ALI20231012BHEP C07D 405/14 20060101ALI20231012BHEP C07D 405/12 20060101ALI20231012BHEP C07D 407/14 20060101ALI20231012BHEP C07D 409/14 20060101ALI20231012BHEP A61K 31/435 20060101ALI20231012BHEP A61P 11/00 20060101ALI20231012BHEP A61P 31/00 20060101ALI20231012BHEP A61P 35/00 20060101ALI20231012BHEP
Designated States
AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Named provisions
Related changes
Get daily alerts for EPO Patent Bulletin - Organic Chemistry (C07D)
Daily digest delivered to your inbox.
Free. Unsubscribe anytime.
Source
About this page
Every important government, regulator, and court update from around the world. One place. Real-time. Free. Our mission
Source document text, dates, docket IDs, and authority are extracted directly from EPO.
The plain-English summary, classification, and "what to do next" steps are AI-generated from the original text. Cite the source document, not the AI analysis.
Classification
Who this affects
Taxonomy
Browse Categories
Get alerts for this source
We'll email you when EPO Patent Bulletin - Organic Chemistry (C07D) publishes new changes.