Mammalian Cell SHMT2 Reduction for Protein Production
Summary
USPTO published patent application US20260098081A1 disclosing isolated mammalian cells with reduced or eliminated SHMT2 expression and methods for using such cells in recombinant protein production. The application names Samuel Peters, James Ravellette, David Razafsky, Jason A. Gustin, and Trissa Borgschulte as inventors. Filing date was September 29, 2023, under application number 19112697.
What changed
USPTO published patent application US20260098081A1 disclosing isolated mammalian cells with reduced or eliminated Serine Hydroxymethyltransferase 2 (SHMT2) expression and methods for preparing such cells. The invention also covers methods for using these cells to produce recombinant proteins.
Biopharmaceutical manufacturers and biotechnology companies developing protein expression systems should monitor this application for potential patent scope implications. If granted, the patent may affect production methods for recombinant proteins, including therapeutic antibodies and other biologics.
What to do next
- Monitor for patent grant or rejection
Archived snapshot
Apr 12, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
METABOLIC SELECTION VIA THE GLYCINE-FORMATE BIOSYNTHESIS PATHWAY
Application US20260098081A1 Kind: A1 Apr 09, 2026
Inventors
Samuel Peters, James Ravellette, David Razafsky, Jason A. Gustin, Trissa Borgschulte
Abstract
The present disclosure provides an isolated mammalian cell comprising a reduced or eliminated expression of Serine Hydroxymethyltransferase 2 (SHMT2). Further provided are methods for preparing such cells and methods for using such cells for the production of recombinant proteins.
CPC Classifications
C07K 16/00 C07K 1/14 C12N 5/0682 C12N 5/10 C12N 9/1014 C12N 9/222 C12Y 201/02001 C07K 2317/31 C12N 2510/02 C12N 2510/04
Filing Date
2023-09-29
Application No.
19112697
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