Japan Science and Technology Agency V-ATPase Inhibitor Patent
Summary
USPTO granted patent US12599588B2 to Japan Science and Technology Agency for an inhibitor of Na+-translocating V-ATPase activity. The compound serves as an antibacterial agent and medicine with applications in antibacterial and screening methods. The patent application was filed January 15, 2020, contains 12 claims, and covers compounds with specific structural features including hydroxy, alkoxy, and amino substituents on phenyl groups.
What changed
USPTO granted patent US12599588B2 to Japan Science and Technology Agency for compounds inhibiting Na+-translocating V-ATPase activity. The patented compounds have applications as antibacterial agents and medicines, including antibacterial and screening methods. The chemical structures include specified substituents on phenyl groups, with R1 representing hydroxy, alkoxy, haloalkoxy, dialkylamino, heterocyclic amine, carboxylic acid amide, bromine, iodine, or hydrocarbon groups.
For pharmaceutical companies developing antibacterial agents, this patent grants exclusive rights to the Japan Science and Technology Agency for V-ATPase inhibitor compounds. Companies pursuing similar compounds or methods should conduct freedom-to-operate analyses to assess potential infringement risks. The patent's 12 claims provide broad protection for the chemical compositions and their applications.
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- Monitor patent database for related patents
- Review patent claims for freedom-to-operate analysis
Archived snapshot
Apr 14, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Inhibitor for V-ATPase activity, antibacterial agent, medicine, antibacterial method and screening method
Grant US12599588B2 Kind: B2 Apr 14, 2026
Assignee
Japan Science and Technology Agency
Inventors
Takeshi Murata, Kouki Shimizu, Fabiana Lica Yakushiji, Katsuhiko Moriyama
Abstract
An inhibitor for Na+-translocating V-ATPase activity including a compound represented by where R1 represents a group selected from a hydroxy group, an alkoxy group, and a haloalkoxy group, each bonded to an adjacent phenyl group via oxygen, or a group selected from a dialkylamino group, a heterocyclic amine, and a carboxylic acid amide group, each bonded to an adjacent phenyl group via nitrogen, or represents bromine, iodine, or a straight-chain hydrocarbon group. R2 represents hydrogen or a haloalkoxy group. Z1 represents an aliphatic hydrocarbon group, an alicyclic hydrocarbon group, an aromatic hydrocarbon group, or a heterocyclic group, each optionally having an arbitrary substituent and having a structure containing a double bond selected from between the group and an adjacent phenyl group. The symbol * represents a bond to the adjacent phenyl group.
CPC Classifications
C07D 401/12 C07D 401/14 C07D 405/14 A61P 35/00 A61K 31/4439 A61K 31/444 A61K 31/497
Filing Date
2020-01-15
Application No.
17423598
Claims
12
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