Injectable bifunctional hydrogel with antibacterial activity for periodontal treatment

ChangeBridge: Patent Grants - Pharma (A61K)

Published March 31st, 2026

Detected March 31st, 2026

Summary

USPTO granted Patent US12589108B2 to Sichuan University for an injectable bifunctional hydrogel with antibacterial activity prepared by dissolving nucleoside analogues in a solvent. The patent covers the hydrogel composition, preparation method, and use for local injection treatment of periodontal disease and craniofacial bone tissue defects. The patent includes 8 claims.

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What changed

USPTO granted Patent US12589108B2 to Sichuan University for an injectable bifunctional hydrogel with antibacterial activity. The bifunctional hydrogel is prepared by dissolving nucleoside analogues and can serve as a candidate drug for local injection treatment of periodontal disease with potential application in craniofacial bone tissue defects. The patent was granted March 31, 2026, with 8 claims covering the composition and method of preparation.\n\nThis is a routine patent issuance creating exclusive IP rights for the assignee. No immediate compliance actions are required. However, entities developing competing periodontal treatments or similar hydrogel technologies should review the patent claims to assess potential freedom-to-operate issues or licensing needs.

Source document (simplified)

← USPTO Patent Grants

Injectable bifunctional hydrogel with antibacterial activity as well as the preparative method and the use thereof

Grant US12589108B2 Kind: B2 Mar 31, 2026

Assignee

SICHUAN UNIVERSITY

Inventors

Hang Zhao, Jiang Liu, Yanan Zhang, Xianglong Han, Qianming Chen

Abstract

An injectable bifunctional hydrogel has antibacterial activity. The bifunctional hydrogel is a hydrogel prepared by dissolving nucleoside analogues in a solvent. The nucleoside analog has a structure of formula I. It can be a candidate drug for the local injection treatment of periodontal disease, and it also has potential application prospects in the minimally invasive treatment of craniofacial bone tissue defects.