Nanjing University of Chinese Medicine - US12600724B2 Indole Alkaloid Compound and Preparation Method
Summary
The USPTO granted Patent US12600724B2 to Nanjing University of Chinese Medicine for an indole alkaloid compound represented by formula (I), including its preparation method and pharmaceutical salts. The compound has demonstrated therapeutic effects in animal studies, including promoting axon growth in peripheral sensory neurons, improving nerve conduction velocity in diabetic rats, accelerating foot ulcer wound healing, reducing pulmonary fibrosis, and protecting lung tissues. The patent contains 13 claims covering the compound, formulations, and methods of treatment for diabetic complications.
What changed
The USPTO issued Patent US12600724B2 to Nanjing University of Chinese Medicine for an indole alkaloid compound with therapeutic applications in diabetic complications. The patent covers the compound, its preparation method, pharmaceutical salts, prodrugs, metabolites, and isomers. Experimental data in the patent demonstrates the compound's efficacy in promoting peripheral sensory neuron axon growth, improving nerve conduction velocity, and healing diabetic foot ulcers in rat models.
For pharmaceutical companies developing treatments for diabetic neuropathy or diabetic foot ulcers, this patent represents potential licensing opportunities or a competitive constraint requiring freedom-to-operate analysis. The patent's broad claim scope covering multiple forms of the compound and therapeutic uses may limit market entry for similar indole alkaloid-based therapies without licensing arrangements with the patent holder.
What to do next
- Monitor patent landscape for freedom-to-operate considerations
- Review patent claims for potential licensing opportunities
- Conduct prior art searches before developing similar compounds
Archived snapshot
Apr 15, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Indole alkaloid and preparation method and use thereof
Grant US12600724B2 Kind: B2 Apr 14, 2026
Assignee
NANJING UNIVERSITY OF CHINESE MEDICINE
Inventors
Xu Shen, Sheng Jiang, Kuojun Zhang, Jiaying Wang, He Tang, Yujie Huang, Tong Zhao, Minyi Qian
Abstract
A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they also show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.
CPC Classifications
C07D 471/22 A61K 31/4375 A61K 31/765 A61K 38/00 A61P 11/00 A61P 17/02 A61P 25/02 A61P 3/10 Y02P 20/55 C07K 5/06139 C07K 5/0821 C08G 65/33396 C07B 2200/07
Filing Date
2022-11-09
Application No.
18264435
Claims
13
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