Markers, Conjugates, Compositions and Methods for Hypoxia Imaging, Mapping, and Therapy

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Markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy

Grant US12600742B2 Kind: B2 Apr 14, 2026

Assignee

WWIKY Biosciences Inc.

Inventors

Piyush Kumar, Hassan Elsaidi, Leonard Irving Wiebe, Michael Weinfeld

Abstract

Described herein are markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy. A compound comprising bio-reductively activated (BA) arm, linker arm and a mapping click wherein BA contains one for more of substituted or unsubstituted 2/4/5-substituted nitroimidazoles, or substituted benzotriazene-1,4-dioxides, or substituted 1,2,3/1,2,4-triazoles, or substituted 1,4-benzoquinones, or a combination of two homo-or hetero BA moieties, wherein linker arm contains C1-16 alkane, alkene, alkyne, alicyclic or aromatic linkers with or without hetero atoms as in ethers, amine, esters, acid, amides, 5 and 6 membered sugar sings with the substitution as described above, both monosaccharides and disaccharides, wherein mapping click contains one of substituted or unsubstituted —N3-, CN, SCN, substituted alkynes for click chemistry. Said compound undergoes in situ click reaction after its distribution in cells or tissues to link to a reporting group which may be unchelated or chelated with a metal-radioactive or non-radioactive-, or a radiohalogen for PET/SPECT, or a dye for fluorescent/optical reporting group, thus accomplishing hypoxia imaging.

CPC Classifications

C07H 15/26 C07D 245/08 C07D 403/12 C07D 405/14 C07D 405/04 A61K 51/0453 A61K 51/0461 A61K 51/0497

Filing Date

2018-09-19

Application No.

16648338

Claims

5

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