Amgen Heterocyclic Inhibitors for KRAS G12C Mutant Proteins

ChangeBridge: EPO Bulletin - Pharma (A61K)

Published March 18th, 2026

Detected March 25th, 2026

Summary

The European Patent Office has published patent application EP4598917A1 by Amgen Inc. detailing heterocyclic inhibitors for KRAS G12C mutant proteins. This publication relates to potential new therapeutic agents for cancer treatment.

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What changed

European Patent Application EP4598917A1, published on March 18, 2026, by Amgen Inc., describes novel heterocyclic compounds designed as inhibitors for KRAS G12C mutant proteins. The application includes details on the chemical structures, synthesis, and potential therapeutic uses of these compounds, particularly in the treatment of cancers driven by this specific mutation.

This publication represents a new patent filing and does not impose immediate compliance obligations on regulated entities. However, it signifies ongoing innovation in oncology drug development. Companies involved in pharmaceutical research and development, particularly in the field of targeted cancer therapies, should be aware of this patent filing as it may impact future competitive landscapes and licensing opportunities.

Source document (simplified)

← EPO Patent Bulletin

HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF

Publication EP4598917A1 Kind: A1 Mar 18, 2026

Applicants

Amgen Inc.

Inventors

LANMAN, Brian A., BOOKER, Shon, BUTLER, John R., GLIBSTRUP, Emil, HUANG, David, HUSEMOEN, Birgitte, KALLER, Matthew R., KOHN, Todd J., LETH-PETERSEN, Sebastian, LOPEZ, Patricia, LIU, Qingyian, MA, Vu Van, MANONI, Francesco, PEIRO CADAHIA, Jorge, PICKRELL, Alexander J., RAST, Slavko, TAMAYO, Nuria A., WANG, Hui-Ling, ZHANG, Wenhan, ZHU, Kai, BANERJEE, Abhisek

IPC Classifications

C07D 401/14 20060101AFI20240412BHEP C07D 403/14 20060101ALI20240412BHEP C07D 405/14 20060101ALI20240412BHEP C07D 417/14 20060101ALI20240412BHEP A61P 35/00 20060101ALI20240412BHEP A61K 31/506 20060101ALI20240412BHEP

Designated States

AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR

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