Changeflow GovPing Pharma & Drug Safety USPTO Grants Patent for Glutathione Trisulfide ...
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USPTO Grants Patent for Glutathione Trisulfide in Neuroprotection

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Summary

The USPTO has granted a patent (US12582693B2) to The General Hospital Corporation for methods using glutathione trisulfide (GSSSG) in neuroprotection. The patent covers uses in treating neurodegenerative diseases and reducing ischemic injury risk.

Published by USPTO on changeflow.com . Detected, standardized, and enriched by GovPing. Review our methodology and editorial standards .

What changed

The United States Patent and Trademark Office (USPTO) has granted patent US12582693B2 for methods involving the use of glutathione trisulfide (GSSSG) in neuroprotection. The patent, assigned to The General Hospital Corporation, specifically details applications for treating neurodegenerative diseases and mitigating the risk of ischemic injury to the brain, spinal cord, and peripheral nerves. The invention pertains to conditions that compromise blood flow and oxygen delivery, such as those resulting from surgery or trauma.

This patent grant signifies a new intellectual property right for a specific therapeutic method. While not a regulatory rule imposing obligations on other entities, it establishes exclusive rights for the assignee. Companies operating in the pharmaceutical or biotechnology sectors, particularly those involved in neurological treatments or therapies for stroke and trauma, should be aware of this granted patent to avoid potential infringement. No immediate compliance actions are required for external parties, but it impacts the competitive landscape for developing similar treatments.

Archived snapshot

Mar 24, 2026

GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.

← USPTO Patent Grants

Glutathione trisulfide (GSSSG) in neuroprotection

Grant US12582693B2 Kind: B2 Mar 24, 2026

Assignee

The General Hospital Corporation

Inventors

Fumito Ichinose, Eizo Marutani

Abstract

Methods for the use of glutathione trisulfide (GSSSG) in neuroprotection, e.g., in neurodegenerative diseases and to reduce the risk of ischemic injury. The methods can be used, e.g., to reduce risk of injury to brain, spinal cord, and peripheral nerves from ischemia or low blood flow states possibly caused by surgery, trauma, and other conditions that decrease/impair blood flow and or oxygen delivery to the nervous system.

CPC Classifications

A61K 38/063 A61K 9/0019 A61K 9/08 A61K 47/20 A61P 25/00 A61P 25/28 C07K 5/0215 C07K 5/0606 C07K 5/0819

Filing Date

2021-05-11

Application No.

17924622

Claims

5

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Named provisions

Abstract Assignee Inventors Claims

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Last updated

Classification

Agency
USPTO
Published
March 24th, 2026
Instrument
Rule
Legal weight
Binding
Stage
Final
Change scope
Minor
Document ID
US12582693B2

Who this affects

Applies to
Drug manufacturers Healthcare providers Medical device makers
Industry sector
3254 Pharmaceutical Manufacturing 3345 Medical Device Manufacturing
Activity scope
Drug Development Therapeutic Methods
Geographic scope
United States US

Taxonomy

Primary area
Pharmaceuticals
Operational domain
R&D
Topics
Medical Devices Healthcare

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