Genome-wide insulator screening system disclosed
Summary
The USPTO has published a patent application detailing a genome-wide insulator screening system. The system, comprising specific MAI-seq vectors, is designed for high-sensitivity screening of genomic insulators and is applicable to any species.
What changed
This document is a publication of a patent application (US20260085307A1) filed by inventors Lei HUANG, Yuwen LIU, and Xiusheng ZHU. It discloses a genome-wide insulator screening system that utilizes MAI-seq-experiment and MAI-seq-control vectors. The system's design, with specific arrangements of weak promoters, marker target genes, insertion sites, enhancers, and poly A sites, aims for high sensitivity and accuracy in screening genomic insulators across any species, while mitigating the influence of silencers.
While this is a patent application and not a regulatory rule, it represents a novel disclosure in the field of biotechnology and genetics. Companies involved in drug discovery, genetic research, or the development of diagnostic tools may find this technology relevant. Compliance officers should note that patent disclosures can inform future regulatory considerations or intellectual property strategies within their organizations. There are no immediate compliance obligations or deadlines associated with this patent application publication.
Archived snapshot
Mar 27, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
GENOME-WIDE INSULATOR SCREENING SYSTEM AND USE
Application US20260085307A1 Kind: A1 Mar 26, 2026
Inventors
Lei HUANG, Yuwen LIU, Xiusheng ZHU
Abstract
The present disclosure discloses a genome-wide insulator screening system. The system comprises an MAI-seq-experiment vector and an MAI-seq-control vector; core gene elements in the MAI-seq-experiment vector are arranged in following order: a weak promoter, a marker target gene, an insertion site for a sequence to be screened, an enhancer and a poly A site; and core gene elements in the MAI-seq-control vector are arranged in following order: a weak promoter, a marker target gene, an enhancer, an insertion site for the sequence to be screened and a poly A site. This genome-wide insulator screening system, primarily composed of these two vectors, exhibits high sensitivity and can be applied to the screening of genomic insulators in any species. Furthermore, it effectively eliminates the influence of silencers, ensuring high screening accuracy. This system provides important technical support for constructing insulator maps and understanding the characteristics and mechanisms of action of insulators.
CPC Classifications
C12N 15/1082 C12N 15/66 C12Q 1/6806 C12Q 1/6809 C12Q 1/6855 C12Q 1/686 C12Q 1/6869 C12N 2830/50
Filing Date
2025-01-15
Application No.
19021326
Named provisions
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