Composition Comprising Three-Dimensional Astrocyte Bundles and Methods of Making and Using
Summary
The USPTO granted Patent US12599670B2 to the Trustees of the University of Pennsylvania covering compositions comprising three-dimensional astrocyte bundles with bipolar and aligned astrocyte processes, methods of making such compositions through ex vivo machine-driven physical stretching or growth within hydrogel micro-columns, and methods of treating nervous system injury or degeneration by implanting the compositions. The patent contains 25 claims and lists D. Kacy Cullen as inventor.
What changed
USPTO granted Patent US12599670B2 to the Trustees of the University of Pennsylvania on April 14, 2026. The patent covers compositions comprising three-dimensional astrocyte bundles created through ex vivo machine-driven physical stretching of astrocytes maintained in culture, as well as astrocyte compositions with aligned bi-polar processes produced by growth within hydrogel micro-columns. The patent also encompasses methods of manufacturing these compositions and methods of treatment for nervous system injury or degeneration via implantation.
For entities in the medical device and biotechnology sectors, this patent establishes intellectual property rights held by the University of Pennsylvania that may affect research and development activities involving astrocyte-based therapies for neural tissue repair, biomaterial scaffolds for neural applications, and related medical device innovations. Parties engaged in similar research should consider potential licensing requirements or design-around strategies to avoid infringement on the 25 claims granted under this patent.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Composition comprising three-dimensional astrocyte bundles of bi-polar and aligned astrocyte processes and a method of making thereof
Grant US12599670B2 Kind: B2 Apr 14, 2026
Assignee
The Trustees of the University of Pennsylvania
Inventors
D. Kacy Cullen
Abstract
The invention includes a composition comprising an astrocyte comprising aligned and elongated astrocyte processes resulting from ex vivo machine-driven, physical stretching of the astrocyte maintained in culture, as well as a method of making it. The invention also includes a composition comprising an astrocyte comprising aligned bi-polar processes resulting from growth within hydrogel micro-columns in culture, as well as a method of making it. The invention also provides methods of treatment of nervous system injury or degeneration by implanting the compositions of the invention.
CPC Classifications
A61K 35/30 A61K 47/36 A61K 9/0024 A61K 2300/00 A61K 38/17 A61L 27/3604 A61L 27/3675 A61L 2300/412 A61L 2300/604 A61L 2300/606 A61L 2300/64 A61L 2420/00 A61L 2420/06 A61L 2430/32 A61L 27/20 A61L 27/225 A61L 27/227 A61L 27/24 A61L 27/26 A61L 27/34 A61L 27/3878 A61L 27/52 A61L 27/54 A61L 27/58 A61L 31/047 A61L 31/10 A61L 31/14 A61L 31/16 C12N 5/0622 C12N 2533/52 C12N 2533/56 C12N 2533/76 C12N 2533/78 C12N 2533/80 C12N 2533/90 C12N 5/0619 C12N 11/04 C12N 2502/08 C12N 2506/1392 C12N 2510/02 C12N 2510/04 C12N 2533/54 C12N 2533/72 C07K 14/435 C07K 14/47 A61F 2002/30062 A61F 2002/30199 A61F 2210/0004 A61F 2230/0063 A61M 2210/0693 A61N 1/05 A61N 1/375 B29C 55/22 B29K 2067/043 B29K 2067/046 B29K 2295/0056 C12M 25/10 C12M 29/16
Filing Date
2015-12-11
Application No.
15534934
Claims
25
Named provisions
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Source
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