Engineered Ketoreductases for Chiral Alcohol Preparation
Summary
The USPTO has published a patent application (US20260085334A1) for engineered ketoreductase polypeptides developed by Enzymaster (Ningbo) Bio-Engineering Co., Ltd. The patent describes enzymes capable of preparing chiral alcohols with high catalytic activity, stereoselectivity, thermal stability, and solvent tolerance.
What changed
This document is a published patent application from the USPTO detailing engineered ketoreductase polypeptides designed for the efficient and selective preparation of chiral alcohols. Specifically, the invention focuses on enzymes that catalyze the reduction of ethyl 4-chloroacetoacetate to produce ethyl (R)-4-chloro-3-hydroxybutyrate, offering high catalytic activity, stereoselectivity, thermal stability, and solvent tolerance, with potential for high substrate loading and conversion rates.
While this is a patent application and not a regulatory rule, it signifies a development in biotechnology relevant to pharmaceutical and chemical manufacturing. Companies in this sector should be aware of emerging intellectual property in enzyme engineering, as it may impact future production methods for chiral compounds. No immediate compliance actions are required, but monitoring patent landscapes is crucial for innovation and competitive strategy.
Archived snapshot
Mar 27, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
ENGINEERED KETOREDUCTASES FOR THE PREPARATION OF CHIRAL ALCOHOLS AND METHODS THEREOF
Application US20260085334A1 Kind: A1 Mar 26, 2026
Assignee
Enzymaster (Ningbo) Bio-Engineering Co., Ltd.
Inventors
Haibin CHEN, Yafang LIANG, Yingxin ZHANG, Zekun XIA, Ameng ZHOU, Marco BOCOLA, Junpeng XU, Xiao LUO, Jingxian MAO, Ruimei HONG, Xinwei WU, Lei SUN, Yixin DAI, Songxue WANG, Qinli PENG
Abstract
The present disclosure provides an engineered ketoreductase polypeptide capable of preparing chiral alcohols, especially for catalyzing the reduction of ethyl 4-chloroacetoacetate to produce ethyl (R)-4-chloro-3-hydroxybutyrate. The polypeptides has high catalytic activity, high stereoselectivity, better thermal stability and solvent tolerance; the reaction process using engineered ketoreductase polypeptides may have a substrate loading of up to 426 g/L and a conversion of up to 99%.
CPC Classifications
C12P 7/62 C12N 1/20 C12N 9/0006 C12N 11/00 C12N 15/52 C12N 15/70 C12P 7/02 C12P 13/02 C12Y 101/01 C12R 2001/19
Filing Date
2023-05-17
Application No.
18879783
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