ELTA Patent - Enzymatic ADP-ribose Labeling Methods
Summary
USPTO granted patent US12601734B2 to Johns Hopkins University covering ELTA (Enzymatic Labeling of Terminal ADP-ribose) technology for labeling free, protein-conjugated, or nucleic acid-conjugated ADP-ribose molecules at their 2'-OH termini. The patent contains 28 claims and covers applications including fluorescence-based biophysical measurement of PAR-protein interaction, detection of PAR length from cells, and enrichment of ADP-ribosylated peptides for mass spectrometry identification.
What changed
USPTO issued patent US12601734B2 to Johns Hopkins University on April 14, 2026, covering ELTA methods for enzymatic labeling of ADP-ribose containing molecules. The patent claims methods for labeling ADP-ribose monomers and polymers at their 2'-OH termini, with applications in fluorescence biophysics, PAR-protein interaction measurement, PAR length detection, and mass spectrometry enrichment.
This patent grant establishes exclusive intellectual property rights for Johns Hopkins University in the ELTA technology space. Parties interested in developing or using ADP-ribose labeling technologies for research or commercial purposes may need to license this patent from the university to avoid infringement.
Archived snapshot
Apr 18, 2026GovPing captured this document from the original source. If the source has since changed or been removed, this is the text as it existed at that time.
Methods and uses of enzymatic labeling of ADP-ribose containing molecules
Grant US12601734B2 Kind: B2 Apr 14, 2026
Assignee
THE JOHNS HOPKINS UNIVERSITY
Inventors
Anthony K. L. Leung, Yoshinari Ando, Robert L McPherson, Mohsen Badiee, Elad Elkayam
Abstract
Described is ELTA (Enzymatic Labeling of Terminal ADP-ribose) to label free, protein-conjugated, or nucleic acid-conjugated ADP-ribose monomer and polymers at their 2′-OH termini. When coupled with different chemical analogs, ELTA can be used for various applications including fluorescence-based biophysical measurement of PAR-protein interaction, detection of PAR length from cells, and enrichment of ADP-ribosylated peptides for mass spectrometry identification.
CPC Classifications
G01N 33/533 C07H 21/00 C07K 9/00 C12P 19/30 C12P 19/34 C12P 21/005 C12Q 1/6811
Filing Date
2019-04-02
Application No.
17044913
Claims
28
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